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Angiopoietin-Related Protein 4

Known as: Angiopoietin-Like Protein 4, HFARP, Hepatic Fibrinogen/Angiopoietin-Related Protein 
Angiopoietin-related protein 4 (406 aa, ~45 kDa) is encoded by the human ANGPTL4 gene. This protein plays a role in the modulation of signaling… Expand
National Institutes of Health

Related topics

Related topics

10 relations
ANGPTL4 geneANGPTL4 wt AlleleAngiogenesis PromoterExtracellular Space
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Papers overview

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Highly Cited
2014
Highly Cited
2014
Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy.
Animal models link ectopic lipid accumulation to renal dysfunction, but whether this process occurs in the human kidney is… Expand
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Highly Cited
2012
Highly Cited
2012
Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4.
BACKGROUND Increased permeability, predominantly controlled by endothelial junction stability, is an early event in the… Expand
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Highly Cited
2011
Highly Cited
2011
Proteolytic processing of angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on lipoprotein lipase activity.
Angiopoietin-like protein 4 (ANGPTL4) has been associated with a variety of diseases. It is known as an endogenous inhibitor of… Expand
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Highly Cited
2009
Highly Cited
2009
Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans
OBJECTIVE Long-chain fatty acids (LCFAs) contribute to metabolic homeostasis in part via gene regulation. This study's objective… Expand
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Highly Cited
2008
Highly Cited
2008
Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4.
OBJECTIVE Angiopoietin-like protein 4 (Angptl4) is a secreted glycoprotein that has recently been implicated in the regulation of… Expand
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Review
2008
Review
2008
Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?
White adipose tissue is a key endocrine and secretory organ, releasing multiple adipokines, many of which are linked to… Expand
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Highly Cited
2007
Highly Cited
2007
Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes
The effect of hypoxia, induced by incubation under low (1%) oxygen tension or by exposure to CoCl2, on the expression and… Expand
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Highly Cited
2006
Highly Cited
2006
The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity.
Proteins secreted from adipose tissue are increasingly recognized to play an important role in the regulation of glucose… Expand
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Highly Cited
2004
Highly Cited
2004
Oligomerization and regulated proteolytic processing of angiopoietin-like protein 4.
Angiopoietin-like protein 4 (Angptl4) is a recently identified circulating protein expressed primarily in adipose tissue and… Expand
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Highly Cited
2004
Highly Cited
2004
Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4.
Angiopoietin-like protein 4 (Angptl4) is the second member of the angiopoietin-like family of proteins previously shown to… Expand
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