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Angiogenesis/Heparanase Inhibitor PG545
Known as:
PG545
A synthetic heparan sulfate mimetic with potential anti-angiogenic and antineoplastic activity. PG545 inhibits the cleavage of heparan sulfate from…
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National Institutes of Health
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Related topics
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NCIt Antineoplastic Agent Terminology
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Characterising Heparan Sulfate Mimetics as Potential Therapeutics in Alphaviral Diseases
Aroon Supramaniam
2019
Corpus ID: 213796863
Arthritogenic alphaviruses such as chikungunya virus (CHIKV) and Ross River virus (RRV) are transmitted by mosquito vectors, and…
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2018
2018
The addition of the novel heparan sulfate (HS) mimetic PG545 to standard chemotherapy shows promising efficacy in the treatment of ovarian cancer in vitro and in vivo
L. Freyer
2018
Corpus ID: 91649004
2014
2014
The Heparan Sulfate Mimetic, PG545, Induces a Potent Anti-Lymphoma Effect By Enhancing Innate Immune Activation By Endogenous Nucleic Acids.: Abstract# A115
T. Brennan
,
Liwen Lin
,
+4 authors
Yiping Yang
2014
Corpus ID: 58189694
2014
2014
Potent antitumor activity of PG545 in platinum sensitive and resistant ovarian cancer models: Correlation with increases in plasma VEGF and heparanase - implications for clinical testing
B. Winterhoff
2014
Corpus ID: 78164437
2014
2014
Failure to Regenerate After Partial Hepatectomy Is Associated With Neutrophilia and Elevated Serum IL-6 and MCP-1.: Abstract# A114
Navarro N. Alvarez
,
Z. Machaidze
,
+6 authors
H. Yeh
2014
Corpus ID: 79716288
A115 The Heparan Sulfate Mimetic, PG545, Induces a Potent AntiLymphoma Effect By Enhancing Innate Immune Activation By Endogenous…
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2014
2014
Abstract 3695: The utility of plasma vascular endothelial growth factor and heparanase as pharmacodynamic markers following treatment with PG545, a heparan sulfate mimetic: preliminary evidence from…
K. Dredge
,
E. Hammond
,
+5 authors
V. Shridhar
Experimental and Molecular Therapeutics
2014
Corpus ID: 70916440
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Background: The heparan sulfate mimetic PG545 has been…
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2013
2013
1 The PG 500 Series : Novel Heparan Sulfate Mimetics as Potent Angiogenesis and Heparanase Inhibitors for Cancer Therapy
K. Dredge
,
E. Hammond
,
+4 authors
V. Ferro
2013
Corpus ID: 29814640
2012
2012
Abstract LB-309: The heparan sulfate mimetic PG545 increases plasma VEGF and FGF-2 in advanced cancer patients, and significantly inhibits tumor growth in preclinical models of ovarian cancer…
B. Winterhoff
,
Shailendra Giri
,
+4 authors
V. Shridhar
2012
Corpus ID: 76325630
PG545 is a synthetic heparan sulfate (HS) mimetic purported to inhibit angiogenesis via the blockade of VEGF and FGF-2 signaling…
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2011
2011
Abstract 1461: The heparan sulfate mimetic PG545 potently inhibits spontaneous lung metastasis and significantly enhances overall survival in the 4T1 breast carcinoma model
K. Dredge
,
E. Hammond
,
+4 authors
Ian Bytheway
2011
Corpus ID: 71920285
PG545 is a fully synthetic heparan sulfate (HS) mimetic entering Phase I clinical trials for advanced cancer. PG545 inhibits key…
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