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Angiogenesis/Heparanase Inhibitor PG545

Known as: PG545 
A synthetic heparan sulfate mimetic with potential anti-angiogenic and antineoplastic activity. PG545 inhibits the cleavage of heparan sulfate from… 
National Institutes of Health

Related topics

Related topics

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NCIt Antineoplastic Agent Terminology

Papers overview

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2020
2020
Immunomodulatory Activities of the Heparan Sulfate Mimetic PG545.
Heparanase regulates multiple biological activities that enhance tumor growth and metastatic spread. Heparanase cleaves and… 
2019
2019
Correction: The heparan sulfate mimetic PG545 interferes with Wnt/β-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine
[This corrects the article DOI: 10.18632/oncotarget.3214.]. 
2018
2018
Patient derived xenografts (PDX) predict an effective heparanase-based therapy for lung cancer
Heparanase, the sole heparan sulfate (HS) degrading endoglycosidase, regulates multiple biological activities that enhance tumor… 
2018
2018
Dataset on mice body weights and food intake following treatment with PG545
2017
2017
An open-label, multi-center phase I study of the safety and tolerability of the novel immunomodulatory agent PG545 in subjects with advanced solid tumors.
3083Background: PG545 (pixatimod, pINN) is a novel immunomodulatory agent which stimulates dendritic cells (DC) via TLR9/IL-12… 
2015
2015
Tu1891 Feasibility of Non-Invasive Method of Diagnosing Pancreatic Fibrosis Using Shear Wave Elastography
2014
2014
The Heparan Sulfate Mimetic, PG545, Induces a Potent Anti-Lymphoma Effect By Enhancing Innate Immune Activation By Endogenous Nucleic Acids.: Abstract# A115
2013
2013
1 The PG 500 Series : Novel Heparan Sulfate Mimetics as Potent Angiogenesis and Heparanase Inhibitors for Cancer Therapy
2012
2012
The dual angiogenesis/metastasis inhibitor PG545 inhibits growth factor-induced cell migration and invasion in vitro and tumor growth in vivo of ovarian cancer cells
2011
2011
Abstract 1461: The heparan sulfate mimetic PG545 potently inhibits spontaneous lung metastasis and significantly enhances overall survival in the 4T1 breast carcinoma model
PG545 is a fully synthetic heparan sulfate (HS) mimetic entering Phase I clinical trials for advanced cancer. PG545 inhibits key… 
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