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Amyloidogenesis

Amyloidogenesis is the formation or growth of amyloid structures, implicated in many human diseases including Alzheimer s disease (AD), Parkinson s… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models
BackgroundNeuroinflammation is important in the pathogenesis and progression of Alzheimer disease (AD). Previously, we… 
Review
2011
Review
2011
The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations
Review
2011
Review
2011
AMP‐activated protein kinase: a potential player in Alzheimer’s disease
J. Neurochem. (2011) 118, 460–474. 
Highly Cited
2008
Highly Cited
2008
Lipid peroxidation up‐regulates BACE1 expression in vivo: a possible early event of amyloidogenesis in Alzheimer’s disease
Increased lipid peroxidation is shown to be an early event of Alzheimer’s disease (AD). However, it is not clear whether and how… 
Highly Cited
2005
Highly Cited
2005
The Fetal Basis of Amyloidogenesis: Exposure to Lead and Latent Overexpression of Amyloid Precursor Protein and β-Amyloid in the Aging Brain
The fetal basis of adult disease (FeBAD) hypothesis states that many adult diseases have a fetal origin. According to FeBAD… 
Highly Cited
2004
Highly Cited
2004
Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.
Analogues of diflunisal, an FDA-approved nonsteroidal antiinflammatory drug (NSAID), were synthesized and evaluated as inhibitors… 
Highly Cited
2004
Highly Cited
2004
Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease.
Highly Cited
2000
Highly Cited
2000
Mechanisms of amyloidogenesis
  • J. Kelly
  • Nature Structural Biology
  • 2000
  • Corpus ID: 27128298
Limitations of the three putative mechanisms of amyloid fibril assembly for explaining Sup35 prion formation have led to the… 
Highly Cited
1999
Highly Cited
1999
Caspase-6 Role in Apoptosis of Human Neurons, Amyloidogenesis, and Alzheimer’s Disease*
Neuronal cell death, neurofibrillary tangles, and amyloid β peptide (Aβ) deposition depict Alzheimer’s disease (AD) pathology… 
Highly Cited
1995
Highly Cited
1995
Interaction of the anthracycline 4'-iodo-4'-deoxydoxorubicin with amyloid fibrils: inhibition of amyloidogenesis.
All types of amyloidosis are structurally characterized by the cross beta-pleated sheet conformation of the fibrils, irrespective… 
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