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Ampligen

 
National Institutes of Health

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Rintatolimod

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Highly Cited
2009
Highly Cited
2009
A clinical grade poly I:C-analogue (Ampligen) promotes optimal DC maturation and Th1-type T cell responses of healthy donors and cancer patients in vitro.
Maturation of dendritic cells (DC) can be triggered in vitro by inflammatory cytokines or Toll-like receptor (TLR) ligands such… Expand
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Highly Cited
2009
Highly Cited
2009
A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo
Abstract Severe acute respiratory syndrome (SARS) is a highly lethal emerging disease caused by coronavirus SARS-CoV. New… Expand
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Highly Cited
2006
Highly Cited
2006
Evaluation of Immunomodulators, Interferons and Known in Vitro SARS-CoV Inhibitors for Inhibition of SARS-Cov Replication in BALB/c Mice
Compounds approved for therapeutic use and in vitro inhibitors of severe acute respiratory syndrome coronavirus (SARS-CoV) were… Expand
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Highly Cited
2004
Highly Cited
2004
Effect of Interferon-Alpha and Interferon-Inducers on West Nile Virus in Mouse and Hamster Animal Models
The recent West Nile virus (WNV) outbreak in the United States has increased the need to identify effective therapies. Studies… Expand
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Highly Cited
2004
Highly Cited
2004
The Interferon Inducer Ampligen [Poly(I)-Poly(C12U)] Markedly Protects Mice against Coxsackie B3 Virus-Induced Myocarditis
ABSTRACT Viral replication, as well as an immunopathological component, is assumed to be involved in coxsackie B virus-induced… Expand
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Review
2003
Review
2003
Dendritic cell (DC) based therapy for cervical cancer: use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]:poly [C(12)U…
Human papilloma virus (HPV) found in 99.7% of cervical cancers represents an attractive immunotherapeutic target for novel… Expand
Highly Cited
2003
Highly Cited
2003
Interferons, Interferon Inducers, and Interferon-Ribavirin in Treatment of Flavivirus-Induced Encephalitis in Mice
ABSTRACT We evaluated the prophylactic and therapeutic efficacy of interferon α-2b, pegylated interferon α-2b, poly(I · C), and… Expand
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1991
1991
Mismatched double-stranded RNA, Ampligen (poly(I): poly(C12U), demonstrates antiviral and immunostimulatory activities in HIV disease.
Mismatched double-stranded RNA (Ampligen) has broad spectrum antiviral and immunomodulatory activities. These activities generate… Expand
Highly Cited
1987
Highly Cited
1987
CLINICAL, IMMUNOLOGICAL, AND VIROLOGICAL EFFECTS OF AMPLIGEN, A MISMATCHED DOUBLE-STRANDED RNA, IN PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX
10 patients with the acquired immunodeficiency syndrome (AIDS), AIDS-related complex (ARC), or lymphadenopathy syndrome (LAS… Expand
1987
1987
MISMATCHED DOUBLE-STRANDED RNA (AMPLIGEN) REDUCES CONCENTRATION OF ZIDOVUDINE (AZIDOTHYMIDINE) REQUIRED FOR IN-VITRO INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS
'Ampligen', a non-toxic, mismatched polymer of double-stranded RNA with antiviral and immunomodulatory activities reduced the… Expand
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