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Ampligen

 
National Institutes of Health

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Rintatolimod

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Highly Cited
2009
Highly Cited
2009
A clinical grade poly I:C-analogue (Ampligen) promotes optimal DC maturation and Th1-type T cell responses of healthy donors and cancer patients in vitro.
Maturation of dendritic cells (DC) can be triggered in vitro by inflammatory cytokines or Toll-like receptor (TLR) ligands such… Expand
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Highly Cited
2007
Highly Cited
2007
Cross-protection against H5N1 influenza virus infection is afforded by intranasal inoculation with seasonal trivalent inactivated influenza vaccine.
BACKGROUND Avian H5N1 influenza A virus is an emerging pathogen with the potential to cause substantial human morbidity and… Expand
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2007
2007
Intranasal immunization with H5N1 vaccine plus Poly I:Poly C12U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challenge.
The avian H5N1 influenza virus has the potential to cause a new pandemic. Since it is difficult to predict which strain of… Expand
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2007
2007
Effect of exogenous interferon and an interferon inducer on western equine encephalitis virus disease in a hamster model.
Mice are used as models for western equine encephalitis virus (WEEV) infection, but high mortality is generally only seen with… Expand
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Highly Cited
2005
Highly Cited
2005
Preparation of human ovarian cancer ascites-derived exosomes for a clinical trial.
Despite initial response to chemotherapy, at least 50% of ovarian cancer patients will relapse within 18 months. Progression-free… Expand
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2004
2004
The interferon inducer ampligen [poly(I)-poly(C12U)] markedly protects mice against coxsackie B3 virus-induced myocarditis.
Viral replication, as well as an immunopathological component, is assumed to be involved in coxsackie B virus-induced myocarditis… Expand
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Highly Cited
2004
Highly Cited
2004
Effect of Interferon-Alpha and Interferon-Inducers on West Nile Virus in Mouse and Hamster Animal Models
The recent West Nile virus (WNV) outbreak in the United States has increased the need to identify effective therapies. Studies… Expand
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Review
2003
Review
2003
Dendritic cell (DC) based therapy for cervical cancer: use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]:poly [C(12)U…
Human papilloma virus (HPV) found in 99.7% of cervical cancers represents an attractive immunotherapeutic target for novel… Expand
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1993
1993
Treatment of lethal Pichinde virus infections in weanling LVG/Lak hamsters with ribavirin, ribamidine, selenazofurin, and ampligen.
A lethal Pichinde (An 4763 strain) virus infection was produced in 3-week-old random-bred Golden Syrian (LVG/Lak strain) hamsters… Expand
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1987
1987
CLINICAL, IMMUNOLOGICAL, AND VIROLOGICAL EFFECTS OF AMPLIGEN, A MISMATCHED DOUBLE-STRANDED RNA, IN PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX
10 patients with the acquired immunodeficiency syndrome (AIDS), AIDS-related complex (ARC), or lymphadenopathy syndrome (LAS… Expand
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