Amikacin

Known as: O-3-amino-3-Deoxy-alpha-D-glucopyranosyl-(1->4)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->6))-N(3)-(4-amino-L-2-hydroxybutyryl)-2-deoxy-L-streptamine, Amikacina, Amicacin 
A broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
RATIONALE In experimental pneumonia, nebulization of antibiotics provides high lung tissue concentrations and rapid bacterial… (More)
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Highly Cited
2010
Highly Cited
2010
INTRODUCTION It has been proposed that doses of amikacin of >15 mg/kg should be used in conditions associated with an increased… (More)
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Highly Cited
2008
Highly Cited
2008
OBJECTIVES Chronic infections of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients are intractable antibiotic… (More)
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Highly Cited
2005
Highly Cited
2005
Capreomycin, kanamycin, amikacin, and viomycin are drugs that are used to treat multidrug-resistant tuberculosis. Each inhibits… (More)
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Highly Cited
2002
Highly Cited
2002
Pseudomonas aeruginosa carries multiresistance plasmids less often than does Klebsiella pneumoniae, develops mutational… (More)
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Highly Cited
1998
Highly Cited
1998
An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical… (More)
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Highly Cited
1996
Highly Cited
1996
Combinations of beta-lactams plus aminoglycosides have been standard therapy for suspected infections in granulocytopenic cancer… (More)
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Highly Cited
1995
Highly Cited
1995
Gram-positive bacteria have become the predominant infecting organisms in granulocytopenic cancer patients. Empiric antibiotic… (More)
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Review
1989
Review
1989
 
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Highly Cited
1987
Highly Cited
1987
To determine whether combination antibiotic therapy including a short course of an aminoglycoside was as effective and less toxic… (More)
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