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Ambenonium

Known as: Ambenonium base, Ambenonum, Benzenemethanaminium, N,N'-((1,2-dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl))bis(2-chloro-N,N-diethyl)- 
A bisquaternary ammonium alcohol with parasympathomimetic activity. The positive charge of ambenonium allows it to act as an acetylcholinesterase… 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (2)

Ambenonium ChlorideMytelase
Poisoning by parasympathomimetics (cholinergics)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Slow-binding inhibition of acetylcholinesterase by an alkylammonium derivative of 6-methyluracil: mechanism and possible advantages for myasthenia gravis treatment.
Inhibition of human AChE (acetylcholinesterase) and BChE (butyrylcholinesterase) by an alkylammonium derivative of 6-methyluracil… 
Highly Cited
2007
Highly Cited
2007
Characterization of reversible and pseudo-irreversible acetylcholinesterase inhibitors by means of an immobilized enzyme reactor.
Highly Cited
2003
Highly Cited
2003
Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider mite, Tetranychus urticae.
Highly Cited
2001
Highly Cited
2001
Reversible and irreversible acetylcholinesterase inhibitors cause changes in neuronal amyloid precursor protein processing and protein kinase C level in vitro
1992
1992
Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities.
Steady state patterns of inhibition of purified human erythrocyte acetylcholinesterase by three inhibitors were analyzed… 
Highly Cited
1978
Highly Cited
1978
ACETYLCHOLINESTERASE IN THE SUBSTANTIA NIGRA AND CAUDATE‐PUTAMEN OF THE RAT: PROPERTIES AND LOCALIZATION IN DOPAMINERGIC NEURONS
Abstract— In order to examine the hypothesis that acetylcholinesterase (AChE) is contained within dopaminergic neurons of the… 
Highly Cited
1971
Highly Cited
1971
The synthesis, turnover and release of surplus acetylcholine in a sympathetic ganglion
1. Surplus acetylcholine (ACh) is the extra ACh that accumulates in cholinergic nerve endings when they are exposed to an… 
1969
1969
Apparent dissociation constants for several inhibitors of acetylcholinesterase in the intact electroplax of the electric eel.
1968
1968
A comparison of the action of facilitatory and depolarizing drugs at the mammalian motor nerve terminal.
1967
1967
The action of facilitatory drugs on the isolated tenuissimus muscle of the cat.
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