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Alkylphosphocholine Compound
Known as:
Alkylphospholipid
, APC
, Alkylphospholipids
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An ether-linked lysophosphatidylcholine with potential antineoplastic activity. Exhibiting anti-proliferative and immunomodulatory properties, alkyl…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Lipid rafts, endoplasmic reticulum and mitochondria in the antitumor action of the alkylphospholipid analog edelfosine.
C. Gajate
,
F. Mollinedo
Anti-Cancer Agents in Medicinal Chemistry
2014
Corpus ID: 4488075
The so-called alkylphospholipid analogs (APLs) constitute a family of synthetic antitumor compounds that target cell membranes…
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Highly Cited
2012
Highly Cited
2012
Perifosine sensitizes curcumin‐induced anti‐colorectal cancer effects by targeting multiple signaling pathways both in vivo and in vitro
Min-bin Chen
,
Xiao-yang Wu
,
+4 authors
Pei-hua Lu
International Journal of Cancer
2012
Corpus ID: 10953902
Our study shows that coadministration of curcumin and an orally bioactive alkylphospholipid perifosine results in a significant…
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Review
2007
Review
2007
Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy.
S. Vink
,
W. V. van Blitterswijk
,
J. Schellens
,
M. Verheij
Cancer Treatment Reviews
2007
Corpus ID: 25953633
Highly Cited
2006
Highly Cited
2006
Phase I and pharmacokinetic study of combined treatment with perifosine and radiation in patients with advanced solid tumours.
S. Vink
,
J. Schellens
,
+7 authors
M. Verheij
Radiotherapy and Oncology
2006
Corpus ID: 20086128
Highly Cited
2006
Highly Cited
2006
Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells
Lorena de la Peña
,
W. Burgan
,
+4 authors
P. Tofilon
Molecular Cancer Therapeutics
2006
Corpus ID: 11737664
Akt has been implicated as a molecular determinant of cellular radiosensitivity. Because it is often constitutively activated or…
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2004
2004
Decreased levels of osteopontin and bone sialoprotein II are correlated with reduced proliferation, colony formation, and migration of GFP-MDA-MB-231 cells.
H. Adwan
,
T. Bäuerle
,
Y. Najajreh
,
V. Elazer
,
G. Golomb
,
M. Berger
International Journal of Oncology
2004
Corpus ID: 46571509
MDA-MB-231 human breast cancer cells transfected with GFP were used as model to determine the reduction in proliferation, colony…
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2002
2002
Combination effects of alkylphosphocholines and gemcitabine in malignant and normal hematopoietic cells.
M. Georgieva
,
S. Konstantinov
,
M. Topashka-Ancheva
,
M. Berger
Cancer Letters
2002
Corpus ID: 22097066
Highly Cited
2000
Highly Cited
2000
Visceral leishmanicidal activity of hexadecylphosphocholine (miltefosine) in mice deficient in T cells and activated macrophage microbicidal mechanisms.
Henry W. Murray
,
Sharmaine Delph-Etienne
Journal of Infectious Diseases
2000
Corpus ID: 15674610
Hexadecylphosphocholine (miltefosine), a membrane-active alkylphospholipid, may be the first effective oral agent for visceral…
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Highly Cited
1991
Highly Cited
1991
The phospholipid analogue, hexadecylphosphocholine, inhibits protein kinase C in vitro and antagonises phorbol ester-stimulated cell proliferation.
C. Geilen
,
R. Haase
,
K. Buchner
,
T. Wieder
,
F. Hucho
,
W. Reutter
European Journal of Cancer
1991
Corpus ID: 31787952
Highly Cited
1985
Highly Cited
1985
Synthetic alkylphospholipid analogues: a new class of antitumor agents
W. Berdel
,
R. Andreesen
,
P. G. Munder
1985
Corpus ID: 83152733
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