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Alkylphosphocholine Compound

Known as: Alkylphospholipid, APC, Alkylphospholipids 
An ether-linked lysophosphatidylcholine with potential antineoplastic activity. Exhibiting anti-proliferative and immunomodulatory properties, alkyl… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Lipid rafts, endoplasmic reticulum and mitochondria in the antitumor action of the alkylphospholipid analog edelfosine.
The so-called alkylphospholipid analogs (APLs) constitute a family of synthetic antitumor compounds that target cell membranes… 
Highly Cited
2012
Highly Cited
2012
Perifosine sensitizes curcumin‐induced anti‐colorectal cancer effects by targeting multiple signaling pathways both in vivo and in vitro
Our study shows that coadministration of curcumin and an orally bioactive alkylphospholipid perifosine results in a significant… 
Review
2007
Review
2007
Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy.
Highly Cited
2006
Highly Cited
2006
Phase I and pharmacokinetic study of combined treatment with perifosine and radiation in patients with advanced solid tumours.
Highly Cited
2006
Highly Cited
2006
Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells
Akt has been implicated as a molecular determinant of cellular radiosensitivity. Because it is often constitutively activated or… 
2004
2004
Decreased levels of osteopontin and bone sialoprotein II are correlated with reduced proliferation, colony formation, and migration of GFP-MDA-MB-231 cells.
MDA-MB-231 human breast cancer cells transfected with GFP were used as model to determine the reduction in proliferation, colony… 
2002
2002
Combination effects of alkylphosphocholines and gemcitabine in malignant and normal hematopoietic cells.
Highly Cited
2000
Highly Cited
2000
Visceral leishmanicidal activity of hexadecylphosphocholine (miltefosine) in mice deficient in T cells and activated macrophage microbicidal mechanisms.
Hexadecylphosphocholine (miltefosine), a membrane-active alkylphospholipid, may be the first effective oral agent for visceral… 
Highly Cited
1991
Highly Cited
1991
The phospholipid analogue, hexadecylphosphocholine, inhibits protein kinase C in vitro and antagonises phorbol ester-stimulated cell proliferation.
Highly Cited
1985
Highly Cited
1985
Synthetic alkylphospholipid analogues: a new class of antitumor agents
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