FAQ

Alkylphosphocholine Compound

Known as: Alkylphospholipid, APC, Alkylphospholipids 
An ether-linked lysophosphatidylcholine with potential antineoplastic activity. Exhibiting anti-proliferative and immunomodulatory properties, alkyl… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2018
024619952018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Alkylphosphocholine analogs for broad-spectrum cancer imaging and therapy.
Many solid tumors contain an overabundance of phospholipid ethers relative to normal cells. Capitalizing on this difference, we… (More)
Is this relevant?
2010
2010
Erucylphosphohomocholine, the first intravenously applicable alkylphosphocholine, is cytotoxic to acute myelogenous leukemia cells through JNK- and PP2A-dependent mechanisms
Alkylphospholipids and alkylphosphocholines (APCs) are promising antitumor agents, which target the plasma membrane and affect… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
2010
2010
Targeting the PI3K/Akt Cell Survival Pathway to Induce Cell Death of HIV-1 Infected Macrophages with Alkylphospholipid Compounds
BACKGROUND HIV-1 infected macrophages and microglia are long-lived viral reservoirs persistently producing viral progenies. HIV-1… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2010
2010
Disruption of cellular cholesterol transport and homeostasis as a novel mechanism of action of membrane-targeted alkylphospholipid analogues.
BACKGROUND AND PURPOSE Alkylphospholipid (APL) analogues constitute a new class of synthetic anti-tumour agents that act directly… (More)
Is this relevant?
2008
2008
Alkylphospholipids inhibit capillary-like endothelial tube formation in vitro: antiangiogenic properties of a new class of antitumor agents.
Synthetic alkylphospholipids (APLs), such as edelfosine, miltefosine and perifosine, constitute a new class of antineoplastic… (More)
Is this relevant?
2004
2004
Transcriptional Activation of p21 by Alkylphospholipids: Role of the Mitogen-Activated Protein Kinase Pathway in the Transactivation of the Human p21 Promoter by Sp1
Alkylphospholipids (ALKs) are a novel class of antitumor agents with an unknown mechanism of action. The first ALK tested in the… (More)
  • figure 2
  • figure 1
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2004
2004
Alkylphosphocholine-induced glioma cell death is BCL-XL-sensitive, caspase-independent and characterized by massive cytoplasmic vacuole formation
AbstractAlkylphosphocholines (APC) are candidate anticancer agents. We here report that APC induce the formation of large… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2003
2003
Alkylphospholipids reversibly open epithelial tight junctions.
Alkylphospholipids, such as the antitumor ether lipid 1-O-octadecyl-2-O-methylglycero-3-phosphocholine, modulate cancer cell… (More)
Is this relevant?
2002
2002
Perifosine, a novel alkylphospholipid, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle…
Alkylphospholipids (ALKs) are a novel class of antineoplastic compounds that display potent antiproliferative activity against… (More)
Is this relevant?
1995
1995
Alkylphosphocholine-induced production of nitric oxide and tumor necrosis factor α by U 937 cells
The human histiocytic cell line U937, which expresses a number of monocyte markers and properties, was investigated with regard… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • table 2
Is this relevant?