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Aldehyde Dehydrogenase, Mitochondrial, human

Known as: ALDM, ALDH-E2, Aldehyde Dehydrogenase, Mitochondrial 
Aldehyde dehydrogenase mitochondrial protein (517 aa, ~56 kDa) is encoded by the human ALDH2 gene. This protein is involved in intermediary… 
National Institutes of Health

Related topics

Related topics

15 relations
ALDH2 geneCarbohydrate MetabolismEnzyme GeneGlycerolipid Metabolism Pathway

Broader (1)

Aldehyde Dehydrogenase Mitochondrial

Papers overview

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Highly Cited
2008
Highly Cited
2008
Age-Dependent Neurodegeneration Accompanying Memory Loss in Transgenic Mice Defective in Mitochondrial Aldehyde Dehydrogenase 2 Activity
Oxidative stress may underlie age-dependent memory loss and cognitive decline. Toxic aldehydes, including 4-hydroxy-2-nonenal… 
Highly Cited
2006
Highly Cited
2006
Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin.
Glyceryl trinitrate (GTN), also known as nitroglycerin, has been used to treat angina and heart failure for more than 130 years… 
Highly Cited
2003
Highly Cited
2003
Role of mitochondrial aldehyde dehydrogenase in nitrate tolerance.
Glyceryl trinitrate (GTN) is used in the treatment of angina pectoris and cardiac failure, but the rapid onset of GTN tolerance… 
Highly Cited
1998
Highly Cited
1998
Molecular Cloning, Characterization, and Potential Roles of Cytosolic and Mitochondrial Aldehyde Dehydrogenases in Ethanol Metabolism in Saccharomyces cerevisiae
ABSTRACT The full-length DNAs for two Saccharomyces cerevisiaealdehyde dehydrogenase (ALDH) genes were cloned and expressed… 
Highly Cited
1997
Highly Cited
1997
Involvement of Glutamate 399 and Lysine 192 in the Mechanism of Human Liver Mitochondrial Aldehyde Dehydrogenase*
Mutation to the conserved Glu399 or Lys192 caused the rate-limiting step of human liver mitochondrial aldehyde dehydrogenase… 
Highly Cited
1996
Highly Cited
1996
The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion.
Deficiency in mitochondrial aldehyde dehydrogenase (ALDH2), a tetrameric enzyme, results from inheriting one or two ALDH2*2… 
Review
1986
Review
1986
Racial differences in alcohol sensitivity.
The existence of racial differences in alcohol sensitivity between Oriental and Caucasian populations has been well documented… 
Highly Cited
1985
Highly Cited
1985
Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2.
Partial cDNA clones encoding human cytosolic aldehyde dehydrogenase (ALDH1) and mitochondrial aldehyde dehydrogenase (ALDH2) were… 
Highly Cited
1983
Highly Cited
1983
Isolation and characterization of aldehyde dehydrogenase isozymes from usual and atypical human livers.
Highly Cited
1982
Highly Cited
1982
Structural mutation in a major human aldehyde dehydrogenase gene results in loss of enzyme activity.
Most Caucasians have two major liver aldehyde dehydrogenase isozymes, ALDH1 and ALDH2, while approximately 50% of Orientals have… 
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