Alamethicins
National Institutes of Health
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Peptaibol antibiotics are membrane‐active linear peptides of fungal origin that are characterized by a high population of the C…
Alamethicin is a 20-residue peptaibiotic that induces voltage-dependent ion channels in lipid membranes. The mode by which…
Three derivatives of the hydrophobic, channel‐forming peptaibiotic alamethicin (F50/5) have been synthesized, the original Aib…
The pore‐forming properties of native and synthetic alamethicins were investigated in photoreceptor rod outer segments (OS…
The microheterogeneous alamethicin F30 (ALM F30) isolated from the fermentation of Trichoderma viride strain NRRL 3199 was…
The effect of the trichosporin-Bs, peptide antibiotics, on the respiration of mitochondria was investigated. Trichosporin-Bs…
Consistent results were obtained in biological assays of alamethicins on agar gels only when the antibiotics were allowed to…
The use of FAB and FD as well as EI mass spectrometry for the determination of antibiotic structures is described. Neomycins…