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Adaptor Protein Complex 4

Known as: Adaptor Related Protein Complex 4, AP-4 protein complex, Adaptor-Related Protein Complex 4 
An adaptor protein complex involved in transport of molecules between the TRANS-GOLGI NETWORK and the endosomal-lysosomal system.
National Institutes of Health

Related topics

Related topics

12 relations
AP4B1 geneAP4E1 geneAP4M1 geneAP4S1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein trafficking.
Deficiency of the adaptor protein complex 4 (AP-4) leads to childhood-onset hereditary spastic paraplegia (AP-4-HSP): SPG47… 
2020
2020
The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A
The heterotetrameric adaptor protein complex 4 (AP-4) is a component of a protein coat associated with the trans-Golgi network… 
2020
2020
Loss of ap4s1 in zebrafish leads to neurodevelopmental defects resembling spastic paraplegia 52
Autosomal recessive spastic paraplegia 52 is caused by biallelic mutations in AP4S1 which encodes a subunit of the adaptor… 
2020
2020
AP4B1-associated hereditary spastic paraplegia: expansion of phenotypic spectrum related to homozygous p.Thr387fs variant
Biallelic mutations in the AP4B1 gene, encoding adaptor-related protein complex 4 beta-1 subunit, have been recognized as an… 
2019
2019
An investigation of the function of adaptor protein complex 4 (AP-4)
NIHR Cambridge BRC PhD Fellowship awarded to Alexandra K. Davies EMBO Short-Term Fellowship awarded to Alexandra K. Davies… 
Highly Cited
2018
Highly Cited
2018
AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A
Adaptor protein 4 (AP-4) is an ancient membrane trafficking complex, whose function has largely remained elusive. In humans, AP-4… 
2016
2016
Identification of Cargo for Adaptor Protein (AP) Complexes 3 and 4 by Sucrose Gradient Profiling *
Intracellular vesicle trafficking is a fundamental process in eukaryotic cells. It enables cellular polarity and exchange of… 
2016
2016
Genome-wide association study for host response to bovine leukemia virus in Holstein cows.
2015
2015
Contiguous mutation syndrome in the era of high-throughput sequencing
We investigated two siblings, born to consanguineous parents, with neurological features reminiscent of adaptor protein complex 4… 
2013
2013
Genetic association study of adaptor protein complex 4 with cerebral palsy in a Han Chinese population
Adaptor protein complex 4 (AP-4) plays a key role in vesicle formation, trafficking, and sorting processes that are critical for… 
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