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Ad5CMV

A recombinant replication-deficient serotype 5 adenovirus. Containing an expression cassette consisting of the human cytomegalovirus (CMV) promoter… 
National Institutes of Health

Papers overview

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2003
2003
Adenoviral p53 gene transfer in human bladder cancer cell lines: cytotoxicity and synergy with cisplatin.
Highly Cited
2002
Highly Cited
2002
Insulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer.
Insulin-like growth factors (IGFs) have mitogenic and antiapoptotic properties and have been implicated in the development of… 
2000
2000
Synergistic chemosensitization and inhibition of tumor growth and metastasis by adenovirus-mediated P53 gene transfer in human bladder cancer model.
Highly Cited
1999
Highly Cited
1999
The effects of combining ionizing radiation and adenoviral p53 therapy in nasopharyngeal carcinoma.
Highly Cited
1998
Highly Cited
1998
Enhancement of radiosensitivity of wild-type p53 human glioma cells by adenovirus-mediated delivery of the p53 gene.
OBJECT The authors sought to determine whether combining p53 gene transfer with radiation therapy would enhance the therapeutic… 
1997
1997
Cytotoxic effects of Ad5CMV-p53 expression in two human nasopharyngeal carcinoma cell lines.
Nasopharyngeal carcinoma (NPC) is a malignant disease of the head/neck region with a 5-year survival level of approximately 65… 
Highly Cited
1996
Highly Cited
1996
Adenovirus-mediated transfer of a wild-type p53 gene and induction of apoptosis in cervical cancer.
In most cervical cancers, the function of p53 is down regulated. To explore the potential use of p53 in gene therapy for cervical… 
Highly Cited
1995
Highly Cited
1995
In vivo gene therapy with p53 or p21 adenovirus for prostate cancer.
We introduced the gene for wild-type human p53 or p21, a critical downstream mediator of p53-induced growth suppression, into a… 
Highly Cited
1995
Highly Cited
1995
Safety evaluation of Ad5CMV-p53 in vitro and in vivo.
In preparation for a clinical trial of the recombinant p53 adenovirus Ad5CMV-p53 for the treatment of lung cancer, the potential… 
Highly Cited
1994
Highly Cited
1994
High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus.
A replication-defective and helper-independent recombinant p53 adenovirus was generated. The virus, Ad5CMV-p53, carries an… 
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