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Ad5CMV

A recombinant replication-deficient serotype 5 adenovirus. Containing an expression cassette consisting of the human cytomegalovirus (CMV) promoter… 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Phase I, pharmacokinetic, and pharmacodynamic study of intravenously administered Ad5CMV-p53, an adenoviral vector containing the wild-type p53 gene, in patients with advanced cancer.
PURPOSE The purpose of this study was to assess the feasibility of administering Ad5CMV-p53, an adenoviral vector containing the… 
2006
2006
Adenovirus-mediated transfer of human papillomavirus 16 E6/E7 antisense RNA and induction of apoptosis in cervical cancer.
2005
2005
Therapeutic efficacy of adenoviral-mediated p53 gene transfer is synergistically enhanced by combined use of antisense oligodeoxynucleotide targeting clusterin gene in a human bladder cancer model.
To establish a more effective therapeutic strategy against advanced bladder cancer, we investigated the effects of combined… 
2004
2004
In vivo Recombinant Adenovirus-mediated p53 Gene Therapy in a Syngeneic Rat Model for Colorectal Cancer
The p53 gene has a significant role in controlling genomic stability of cancer. The purpose of this study was to evaluate the… 
2003
2003
Development and validation of a real-time PCR assay for the detection and quantitation of p53 recombinant adenovirus in clinical samples from patients treated with Ad5CMV-p53 (INGN 201).
2000
2000
Synergistic chemosensitization and inhibition of tumor growth and metastasis by adenovirus-mediated P53 gene transfer in human bladder cancer model.
2000
2000
Adenoviral-mediated gene therapy with Ad5CMVp53 and Ad5CMVp21 in combination with standard therapies in human breast cancer cell lines.
Our objective was to determine the efficacy of adenoviral-mediated gene therapy with wild-type p53 or p21 in human breast cancer… 
Highly Cited
1999
Highly Cited
1999
The effects of combining ionizing radiation and adenoviral p53 therapy in nasopharyngeal carcinoma.
Highly Cited
1995
Highly Cited
1995
Safety evaluation of Ad5CMV-p53 in vitro and in vivo.
In preparation for a clinical trial of the recombinant p53 adenovirus Ad5CMV-p53 for the treatment of lung cancer, the potential… 
Highly Cited
1995
Highly Cited
1995
Apoptosis induced in human osteosarcoma cells is one of the mechanisms for the cytocidal effect of Ad5CMV-p53.
Recombinant adenovirus Ad5CMV-p53 induced a strong cytocidal effect in Saos-LM2 cells. This cell line, derived from human… 
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