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Ad-ISF35

Known as: Ad-CD154 ISF35, Ad-CD40L ISF35 
A replication-defective adenovirus vector (Ad-ISF35), which encodes a membrane-stabilized, chimeric human-mouse CD40 binding protein (CD40 ligand… 
National Institutes of Health

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NCIt Antineoplastic Agent Terminology

Papers overview

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2017
2017
Immunogenicity Evaluation of Modified Adenovirus Vaccines Expressing Porcine Circovirus Type 2 Capsid Protein in Pigs.
Porcine circovirus type 2 (PCV2) adenovirus vaccine has been reported, but strong immune responses induced by adenovirus vector… 
2012
2012
Intratumoral delivery of CD154 homolog (Ad-ISF35) induces tumor regression: analysis of vector biodistribution, persistence and gene expression
Correction to: Cancer Gene Therapy (2012) 19, 336–344; doi: 10.1038/cgt.2012.6 Information regarding an additional funding agency… 
2010
2010
Ad-ISF35 Intratumoral Administration Induces a Bystander Effect and Immune-Mediated Tumor Rejection with a Safe Vector Biodistribution and Toxicology Profile In a NHL Mouse Model.
Abstract 1470 Ad-ISF35 is a replication-defective adenovirus (Ad) vector encoding a membrane-stable chimeric CD154 (ISF35) that… 
2009
2009
Phase I study of intranodal direct injection of adenovirus encoding recombinant CD40-ligand (Ad-ISF35) in patients with chronic lymphocytic leukemia.
3003 Background: Transduction of chronic lymphocytic leukemia (CLL) cells with replication-defective adenovirus (Ad) encoding a… 
2009
2009
Ad-ISF35-transduced autologous cells promote in vitro and in vivo chemosensitization in patients with 17p-/P53-defective chronic lymphocytic leukemia.
e14552 Background: Transduction of chronic lymphocytic leukemia (CLL) cells with a replication-defective adenovirus (Ad) encoding… 
2007
2007
Inhibition des Tumorwachstums von etablierten HCC-Tumoren und Rezidivprophylaxe durch intratumorale Behandlung mit CD40L-exprimierenden dendritischen Zellen in vivo
Einleitung: Dendritische Zellen (DC) konnen spezifische T-Zellen gegen Tumorantigene stark stimulieren. Ihr Einsatz gegen das HCC… 
2006
2006
Comparative analysis of antitumor activity of CD40L, RANKL, and 4‐1BBL in vivo following intratumoral administration of viral vectors or transduced dendritic cells
The tumor necrosis factor (TNF) family comprises a group of ligands that regulate cell proliferation, differentiation, activation… 
2003
2003
CpG oligodeoxynucleotides enhance the capacity of adenovirus-mediated CD154 gene transfer to generate effective B-cell lymphoma vaccines.
Activation of CD40 by CD154 induces antigen-presenting cells (APC) to express immune costimulatory molecules, thereby enhancing… 
2002
2002
Adenovirus transduction to effect CD40 signalling improves the immune stimulatory activity of myeloma cells
Summary. Neoplastic plasma cells from patients with myeloma fail to stimulate an effective anti‐myeloma immune response, which… 
2001
2001
T cell activation following infection of primary follicle center lymphoma B cells with adenovirus encoding CD154
Purified, high-titer adenovirus encoding murine CD154 (Ad-CD154) or human CD154 (Ad-hCD154) was used to infect lymph node cells… 
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