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Chemotherapeutic Agents in Noncytotoxic Concentrations Increase Antigen Presentation by Dendritic Cells via an IL-12-Dependent Mechanism1
Antineoplastic chemotherapeutic agents may indirectly activate dendritic cells (DCs) by inducing the release of “danger” signals from dying tumor cells. Whereas the direct cytotoxic or inhibitory… Expand
Dendritic Cells in the Cancer Microenvironment
The complexity of the tumor immunoenvironment is underscored by the emergence and discovery of different subsets of immune effectors and regulatory cells. Tumor-induced polarization of immune cell… Expand
Serum interleukin-6 concentration in schizophrenia: Elevation associated with duration of illness
- R. Ganguli, Zanwei Yang, G. Shurin, K. Chengappa, B. Rabin
- Psychology, Medicine
- Psychiatry Research
- 31 January 1994
Using an enzyme immunoassay (ELISA), we measured serum interleukin-6 (IL-6) concentration in 128 schizophrenic patients (24 of whom were never medicated) and in 110 normal control subjects. Mean… Expand
Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies?
- M. Shurin, G. Shurin, +6 authors R. Ferris
- Biology, Medicine
- Cancer and Metastasis Reviews
- 23 September 2006
The tumor microenvironment consists of a variable combination of tumor cells, stromal fibroblasts, endothelial cells and infiltrating leukocytes, such as macrophages, T lymphocytes, and dendritic… Expand
Neuroblastoma-derived gangliosides inhibit dendritic cell generation and function.
- G. Shurin, M. Shurin, S. Bykovskaia, J. Shogan, M. Lotze, E. Barksdale
- Biology, Medicine
- Cancer research
Neuroblastoma (NB), a tumor of the sympathetic nervous system, is the most common extracranial solid tumor in children. NB-derived gangliosides inhibit the functional activity of T and natural killer… Expand
Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure.
Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was… Expand
Small Rho GTPases Regulate Antigen Presentation in Dendritic Cells1
Dendritic cells (DC) are involved in the regulation of innate and adaptive immunity. However, the molecular mechanisms maintaining DC function remain to be elucidated. In this study, we report on the… Expand
Tumor associated regulatory dendritic cells.
Immune effector and regulatory cells in the tumor microenvironment are key factors in tumor development and progression as the pathogenesis of cancer vitally depends on the multifaceted interactions… Expand
Loss of New Chemokine CXCL14 in Tumor Tissue Is Associated with Low Infiltration by Dendritic Cells (DC), while Restoration of Human CXCL14 Expression in Tumor Cells Causes Attraction of DC Both In…
Breast and kidney-expressed chemokine (BRAK) CXCL14 is a new CXC chemokine with unknown function and receptor selectivity. The majority of head and neck squamous cell carcinoma (HNSCC) and some… Expand
Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations
The dose-delivery schedule of conventional chemotherapy, which determines its efficacy and toxicity, is based on the maximum tolerated dose. This strategy has lead to cure and disease control in a… Expand