Acute quadriplegic myopathy

The muscle wasting and impaired muscle function in critically ill intensive care unit (ICU) patients delay recovery from the… Expand

The dramatic muscle wasting, preferential loss of myosin and impaired muscle function in intensive care unit (ICU) patients with… Expand

Acquired neuromuscular disorders have been shown to be very common in critically ill patients receiving prolonged mechanical… Expand

Muscle denervation and concomitant high-dose dexamethasone treatment in rodents produces characteristic pathologic features of… Expand

BACKGROUND The mechanisms underlying acute quadriplegic myopathy (AQM) are poorly understood, partly as a result of the fact that… Expand

We previously demonstrated that muscle fibers become unable to fire action potentials in both patients and an animal model of… Expand

We investigated the changes of muscle proteins in acute quadriplegic myopathy (AQM) using immunohistochemistry and stoichiometry… Expand

OBJECTIVE Long-term treatment with nondepolarizing neuromuscular blocking agents and corticosteroids in the intensive care unit… Expand

In rats treated with high-dose corticosteroids, skeletal muscle that is denervated in vivo (steroid-denervated [S-D]) develops… Expand

We have previously found that muscle is electrically inexcitable in severe acute quadriplegic myopathy (AQM). In contrast, muscle… Expand