Skip to search formSkip to main contentSkip to account menu

Activation, Metabolic

Known as: Metabolic Activation, activation metabolic, metabolic induction 
The conversion of an exogenous substance by a biological system resulting in the production on an active metabolite.
National Institutes of Health

Related topics

Related topics

2 relations
aspects of radiation effectsphysiological aspects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Diesel exhaust influences carcinogenic PAH-induced genotoxicity and gene expression in human breast epithelial cells in culture.
Review
2006
Review
2006
Future of toxicology-metabolic activation and drug design: challenges and opportunities in chemical toxicology.
The issue of chemically reactive drug metabolites is one of growing concern in the pharmaceutical industry inasmuch as some, but… 
Highly Cited
2006
Highly Cited
2006
A comparative study on the antimutagenic properties of aqueous extracts of Aspalathus linearis (rooibos), different Cyclopia spp. (honeybush) and Camellia sinensis teas.
Review
2002
Review
2002
Radiation- and chemical-induced structural chromosome aberrations in human spermatozoa.
Review
2000
Review
2000
Current status of the cytosolic sulfotransferases in the metabolic activation of promutagens and procarcinogens.
Cytosolic sulfotransferases (SULT) catalyze the sulfation of structurally diverse drugs, endogenous compounds and xenobiotics… 
Highly Cited
1984
Highly Cited
1984
Mutagenicity of derivatives and metabolites of 1-nitropyrene: activation by rat liver S9 and bacterial enzymes.
Highly Cited
1980
Highly Cited
1980
Limitations of metabolic activation systems used with in vitro tests for carcinogens.
Important differences between the metabolic activation of 7,12-dimethylbenz[a]anthracene in intact cellular systems and in liver… 
Highly Cited
1978
Highly Cited
1978
The mutagenicity of airborne particulate pollutants.
Highly Cited
1978
Highly Cited
1978
Oxidative metabolites of diethylstilbestrol in the fetal, neonatal and adult mouse.
Highly Cited
1978
Highly Cited
1978
Metabolic deactivation of mutagens in the Salmonella-microsome test
THE Salmonella typhimurium/mammsilmn microsome test of Ames et al.1 has provided a simple and sensitive short term assay for the… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)