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Activation, Metabolic
Known as:
Metabolic Activation
, activation metabolic
, metabolic induction
The conversion of an exogenous substance by a biological system resulting in the production on an active metabolite.
National Institutes of Health
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2 relations
aspects of radiation effects
physiological aspects
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1987
1987
Effect of carcinogenic adducts on transcription by T7 RNA polymerase.
S. Nath
,
M. Lee
,
L. Romano
Nucleic Acids Research
1987
Corpus ID: 12750611
The effect of modifying the T7 promoter-containing plasmid pDR100 with aminofluorene (AF), acetylaminofluorene (AAF), and benzo[a…
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Review
1987
Review
1987
Metabolic activation of xenobiotic stilbene estrogens.
M. Metzler
Federation proceedings
1987
Corpus ID: 20012564
Certain stilbene estrogens, in particular diethylstilbestrol, are established carcinogens in animals and in humans. The question…
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1984
1984
The role of secondary metabolism in the metabolic activation of 7,12-dimethylbenz[a]anthracene by rat liver microsomes.
Maro Christou
,
N. M. Wilson
,
Colin R. Jefcoate
Carcinogenesis
1984
Corpus ID: 19574907
The effect of induction by either phenobarbital (PB) or 3-methylcholanthrene (MC) on the kinetics of both primary and secondary…
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1984
1984
Erythrocyte-mediated metabolic activation detected by SCE.
H. Norppa
,
F. Tursi
Basic life sciences
1984
Corpus ID: 11158039
Microsomal metabolism has proved to be essential for the acti vation of many chemical carcinogens. For this reason in vitro…
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1984
1984
Metabolic activation of the carcinogen N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide by prostaglandin H synthase.
T. Zenser
,
M. Palmier
,
M. Mattammal
,
B. Davis
Carcinogenesis
1984
Corpus ID: 26016085
It has been demonstrated that N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide (NFTA), when fed with the diet, causes transitional…
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1983
1983
Complex effects of retinol on the metabolic activation of 2-aminofluorene.
Elias Balbinder
,
Sally M. Stick
,
Opendra K. Sharma
Environmental Mutagenesis
1983
Corpus ID: 2137233
It has been reported that vitamin A alcohol (retinol) inhibits the mutagenicity of certain carcinogenic agents requiring…
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1983
1983
In vitro metabolic activation of N,N-dibutylnitrosamine in mutagenesis.
E. Suzuki
,
M. Mochizuki
,
Y. Wakabayashi
,
M. Okada
Gan
1983
Corpus ID: 22081194
Enzymatic alpha-hydroxylation is believed to be the initial step in the metabolic activation of mutagenic and carcinogenic…
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1982
1982
Use of metabolic activation systems of tulip bulbs in the ames test for environmental mutagens
K. Higashi
,
K. Ikeuchi
,
Y. Karasaki
Bulletin of Environmental Contamination and…
1982
Corpus ID: 45289434
The effects of trace amounts of PAH on the carcinogenesis in animals and human beings and on the ecology of plants are examined…
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1980
1980
Evaluation of metabolic activation of 7,12-dimethylbenz(a)anthracene in vitro by aroclor 1254-induced rat liver S-9 fraction.
C. Bigger
,
J. Tomaszewski
,
A. W. Andrews
,
A. Dipple
Cancer Research
1980
Corpus ID: 22321098
Short-term assays for detection of chemical carcinogens frequently rely on an Aroclor 1254-induced rat liver S-9 fraction for…
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1979
1979
Mediated mutagenesis of dimethylnitrosamine in Neurospora crassa by various metabolic activation systems.
Wen-Zong Whong
,
Tong-man Ong
Cancer Research
1979
Corpus ID: 27248946
Four metabolic activation systems (growth mediated mycelium extract mediated, host mediated, and organ homogenate mediated) were…
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