Acetylcholinesterase Inhibitors

Known as: Acetylcholinesterase Inhibitor, Acetylcholine Hydrolase Inhibitor, AcCholE Inhibitor 
Any substance that inhibits acetylcholinesterase (AchE), an enzyme that breaks down acetylcholine (Ach) in the synaptic cleft. Inhibition of… (More)
National Institutes of Health

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Cholinesterase Inhibitor [EPC]

Broader (1)

Cholinesterase Inhibitors

Papers overview

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Review
2017
Review
2017
Drug candidates in clinical trials for Alzheimer’s disease
Alzheimer’s disease (AD) is a major form of senile dementia, characterized by progressive memory and neuronal loss combined with… (More)
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Highly Cited
2009
Highly Cited
2009
Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway
The excessive release of cytokines by the immune system contributes importantly to the pathogenesis of inflammatory diseases… (More)
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2008
2008
Acetylcholinesterase inhibitors and Gulf War illnesses.
Increasing evidence suggests excess illness in Persian Gulf War veterans (GWV) can be explained in part by exposure of GWV to… (More)
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Highly Cited
2006
Highly Cited
2006
Anti-inflammatory properties of cholinergic up-regulation: A new role for acetylcholinesterase inhibitors
We investigated the anti-inflammatory effects of acetylcholinesterase inhibitors (AChEI) at the cellular and molecular levels… (More)
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2006
2006
Acetylcholinesterase inhibitors for Alzheimer's disease: anti-inflammatories in acetylcholine clothing!
The pathogenesis of Alzheimer's disease (AD) has been linked to a deficiency in the brain neurotransmitter acetylcholine… (More)
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Highly Cited
2004
Highly Cited
2004
Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza.
Acetylcholinesterase (AChE, EC 3.1.1.7) inhibitors are the only registered drugs used to treat Alzheimer's disease (AD). New AChE… (More)
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Review
2003
Review
2003
CSF markers for incipient Alzheimer's disease
Early diagnosis of Alzheimer's disease (AD) is needed to initiate symptomatic treatment with acetylcholinesterase inhibitors, and… (More)
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Highly Cited
2001
Highly Cited
2001
Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining.
Thin-layer chromatography (TLC) was used to screen for acetylcholinesterase inhibitors from Amaryllidaceae extracts. The TLC… (More)
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Review
2000
Review
2000
Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors.
A wide range of evidence shows that acetylcholinesterase (AChE) inhibitors can interfere with the progression of Alzheimer's… (More)
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Highly Cited
1996
Highly Cited
1996
Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine.
Acetylcholinesterase (AChE) inhibitors from several chemical classes have been tested for the symptomatic treatment of Alzheimer… (More)
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