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D-(-)-Lentiginosine [(-)-4], the nonnatural enantiomer of the iminosugar indolizidine alkaloid L-(+)-lentiginosine, acts as… Expand Pancreatic cancer is highly resistant to the currently available chemotherapeutic agents. Less than 5% of patients diagnosed with… Expand ABSTRACT Caspase 8 is required not only for death receptor-mediated apoptosis but also for lymphocyte activation in the immune… Expand Tomatine adjuvant, consisting of tomatine, n-octyl-beta-d-glucopyranoside (OGP), phosphatidylethanolamine and cholesterol is… Expand Cepharanthine (CEP) is a known membrane stabilizer that has been widely used in Japan for the treatment of several disorders such… Expand Disappearance of antigen presenting cells (APC) from the lymph node occurs following antigen specific interactions with T cells… Expand The mechanism of liver cell injury induced by an overdose of the analgesic acetaminophen (AAP) remains controversial. Recently… Expand During apoptosis, DNA fragmentation and intracellular acidification occur concurrently. Previous results have shown that… Expand OBJECTIVES
Elucidation of the mechanisms of the previously shown growth-inhibitory action of human chorionic gonadotropin (hCG… Expand Previous studies indicate that activation of c-Jun kinase (JNK) is necessary for apoptosis of trophic factor-deprived PC12 cells… Expand