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Abasic Site Formation

Known as: Formation of Abasic Site 
Abasic Site Formation involves the creation of an apurinic or apyrimidinic site resulting from the loss of a purine or pyrimidine residue from DNA.
National Institutes of Health

Related topics

Related topics

3 relations
Base Excision RepairChromosome StructuresDNA Repair

Papers overview

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2018
2018
Pathways of Metabolite-Related Damage to a Synthetic p53 Gene Exon 7 Oligonucleotide Using Magnetic Enzyme Bioreactor Beads and LC-MS/MS Sequencing.
Reactive metabolites of environmental chemicals and drugs can cause site specific damage to the p53 tumor suppressor gene in a… 
2014
2014
Identification of the C4′-Oxidized Abasic Site as the Most Abundant 2-Deoxyribose Lesion in Radiation-Damaged DNA Using a Novel HPLC-Based Approach
A novel analytical high-performance liquid chromatography (HPLC)-based method of quantification of the yields of C4′-oxidized… 
2009
2009
Concerning the hydrolytic stability of 8-aryl-2'-deoxyguanosine nucleoside adducts: implications for abasic site formation at physiological pH.
Direct addition of aryl radical species to the C(8)-site of 2'-deoxyguanosine (dG) affords C(8)-aryl-dG adducts that are produced… 
2007
2007
Detection of labeled abasic sites in damaged DNA by capillary electrophoresis with laser-induced fluorescence
Removal of nucleobases from the DNA backbone leads to the formation of abasic sites. The rate of abasic site formation is… 
1998
1998
Mutagenesis by peroxy radical is dominated by transversions at deoxyguanosine: evidence for the lack of involvement of 8-oxo-dG1 and/or abasic site formation.
Oxidative damage of DNA by endogenously generated oxygen radicals contributes to the mutagenic process. Hydroxy, alkoxy, and… 
1995
1995
Double-stranded damage of DNA.RNA hybrids by neocarzinostatin chromophore: selective C-1' chemistry on the RNA strand.
Glutathione-activated neocarzinostatin chromophore generates bistranded lesions in the hybrid formed by yeast tRNA(phe) and DNA… 
1991
1991
Selective abstraction of 2H from C-5' of thymidylate in an oligodeoxynucleotide by the radical center at C-6 of the diradical species of neocarzinostatin: chemical evidence for the structure of the…
Use has been made of the mechanism of DNA deoxyribose damage by the ene-diyne-containing chromophore of the antitumor antibiotic… 
1990
1990
Abasic oligodeoxyribonucleoside phosphorothioates: synthesis and evaluation as anti-HIV-1 agents.
The syntheses and anti-HIV-1 evaluations of two, abasic oligodeoxyribonucleotide phosphorothioate analogs, d[Cps(Eps)26C] and d… 
1989
1989
DNA strand scission by antitumor antibiotics. Detection of C-4'-hydroxylated abasic sites in DNA.
Detection of C-4'-hydroxylated abasic site in calf thymus DNA was investigated. Upon heating with neutral hydrazine (90 degrees C… 
1988
1988
Atypical abasic sites generated by neocarzinostatin at sequence-specific cytidylate residues in oligodeoxynucleotides.
Neocarzinostatin chromophore produces alkali-labile, abasic sites at cytidylate residues in AGC sequences in oligonucleotides in… 
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