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AZD9668

Known as: AZD 9668, AZD-9668 
National Institutes of Health

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Papers overview

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2020
2020
Abstract P3-10-02: Neutrophil elastase as a therapeutic target to inhibit metastasis in breast cancer
Background: Chronic inflammation, a hallmark of cancer, is associated with poor prognosis in human various malignancies… 
2019
2019
Faculty Opinions recommendation of Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis.
  • M. Metersky
  • Faculty Opinions – Post-Publication Peer Review…
  • 2019
  • Corpus ID: 87436248
Review
2018
Review
2018
Neutrophil elastase increases ciliary beat frequency ex-vivo: implications for the bronchiectasis airway
Rationale: The neutrophil derived protease, Neutrophil elastase (NE), in patient sputum is a biomarker of bronchiectasis severity… 
2015
2015
Feasibility of Computed Tomography in a Multicenter COPD Trial: A Study of the Effect of AZD9668 on Structural Airway Changes
IntroductionThe aim of this study was to establish the feasibility of using computed tomography (CT) in a multicenter setting to… 
2015
2015
Regarding "Elastase inhibitor AZD9668 treatment prevented progression of experimental abdominal aortic aneurysms".
Review
2014
Review
2014
The potential of neutrophil elastase inhibitors as anti-inflammatory therapies
Purpose of reviewTherapeutic inhibition of neutrophil-derived elastases holds promise with powerful treatment effects observed in… 
2014
2014
Oral Ulceration in Behçet's Disease: An Investigation of Neutrophil Elastase and Its Inhibitors
Review
2012
Review
2012
Neutrophil elastase inhibitors: recent advances in the development of mechanism-based and nonelectrophilic inhibitors.
Due to its implication in pathologies of prevalent diseases such as chronic obstructive pulmonary disease, fibrosis… 
2011
2011
Effect Of The Oral Neutrophil Elastase Inhibitor, AZD9668, In Patients With Cystic Fibrosis
2011
2011
Crystalline form of a neutrophil elastase inhibitor, 6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-{[5-(methylsulfonyl)pyridin-2-yl]methyl}-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3…
This patent application claims a novel crystalline form (Form A) of a tosylate salt of a previously disclosed neutrophil elastase… 
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