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AZD7687

 
National Institutes of Health

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Related topics

2 relations

Broader (2)

AcetatesPyrazines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Evolving data analysis of an Oral Lipid Tolerance Test toward the standard for the Oral Glucose Tolerance Test: Cross species modeling effects of AZD7687 on plasma triacylglycerol
We have developed a novel mechanistic pharmacokinetic‐pharmacodynamic (PK/PD) model to describe the time course of plasma… Expand
2015
2015
Pharmacological Inhibition of DGAT1 Induces Sebaceous Gland Atrophy in Mouse and Dog Skin While Overt Alopecia Is Restricted to the Mouse
Diacylglycerol O-acyltransferase 1 (DGAT1) plays an important role in synthesizing lipids, and inhibitors of DGAT1 have been… Expand
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Highly Cited
2014
Highly Cited
2014
Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects: a randomized clinical trial
Inhibition of diacylglycerol acyltransferase 1 (DGAT1) is a potential treatment modality for patients with type 2 diabetes… Expand
2013
2013
Proof of mechanism for the DGAT1 inhibitor AZD7687: results from a first‐time‐in‐human single‐dose study
Inhibition of diacylglycerol acyltransferase 1 (DGAT1), which catalyses the final step in triacylglycerol (TAG) assembly, is… Expand
2013
2013
A one-week phase 1 trial with the DGAT1 inhibitor AZD7687 : lipid handling, hormone secretion and adverse effects in the gut
A one-week phase 1 trial with the DGAT1 inhibitor AZD7687 : lipid handling, hormone secretion and adverse effects in the gut 
2012
2012
Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid…
A new series of pyrazinecarboxamide DGAT1 inhibitors was designed to address the need for a candidate drug with good potency… Expand
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