AZD7687

 
National Institutes of Health

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AcetatesPyrazines

Papers overview

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2019
2019
Evolving data analysis of an Oral Lipid Tolerance Test toward the standard for the Oral Glucose Tolerance Test: Cross species modeling effects of AZD7687 on plasma triacylglycerol
We have developed a novel mechanistic pharmacokinetic-pharmacodynamic (PK/PD) model to describe the time course of plasma… Expand
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2015
2015
Pharmacological inhibition of DGAT1 induces sebaceous gland atrophy in mouse and dog skin while overt alopecia is restricted to the mouse.
Diacylglycerol O-acyltransferase 1 (DGAT1) plays an important role in synthesizing lipids, and inhibitors of DGAT1 have been… Expand
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2014
2014
Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects: a randomized clinical trial.
AIM Inhibition of diacylglycerol acyltransferase 1 (DGAT1) is a potential treatment modality for patients with type 2 diabetes… Expand
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2013
2013
Proof of mechanism for the DGAT1 inhibitor AZD7687: results from a first-time-in-human single-dose study.
AIMS Inhibition of diacylglycerol acyltransferase 1 (DGAT1), which catalyses the final step in triacylglycerol (TAG) assembly, is… Expand
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2013
2013
A one-week phase 1 trial with the DGAT1 inhibitor AZD7687 : lipid handling, hormone secretion and adverse effects in the gut
A one-week phase 1 trial with the DGAT1 inhibitor AZD7687 : lipid handling, hormone secretion and adverse effects in the gut 
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2012
2012
Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid…
A new series of pyrazinecarboxamide DGAT1 inhibitors was designed to address the need for a candidate drug with good potency… Expand
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