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AZD7687
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Acetates
Pyrazines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Evolving data analysis of an Oral Lipid Tolerance Test toward the standard for the Oral Glucose Tolerance Test: Cross species modeling effects of AZD7687 on plasma triacylglycerol
P. Morentin Gutierrez
,
James Yates
,
C. Nilsson
,
Sue Birtles
Pharmacology research & perspectives
2019
Corpus ID: 84846469
We have developed a novel mechanistic pharmacokinetic‐pharmacodynamic (PK/PD) model to describe the time course of plasma…
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2015
2015
Pharmacological Inhibition of DGAT1 Induces Sebaceous Gland Atrophy in Mouse and Dog Skin While Overt Alopecia Is Restricted to the Mouse
E. Floettmann
,
D. Lees
,
F. Seeliger
,
H. Jones
Toxicologic pathology
2015
Corpus ID: 36688980
Diacylglycerol O-acyltransferase 1 (DGAT1) plays an important role in synthesizing lipids, and inhibitors of DGAT1 have been…
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Highly Cited
2014
Highly Cited
2014
Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects: a randomized clinical trial
H. Denison
,
C. Nilsson
,
+6 authors
J. Eriksson
Diabetes, obesity & metabolism
2014
Corpus ID: 29736433
Inhibition of diacylglycerol acyltransferase 1 (DGAT1) is a potential treatment modality for patients with type 2 diabetes…
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2013
2013
Proof of mechanism for the DGAT1 inhibitor AZD7687: results from a first‐time‐in‐human single‐dose study
H. Denison
,
C. Nilsson
,
+4 authors
J. Eriksson
Diabetes, obesity & metabolism
2013
Corpus ID: 20564704
Inhibition of diacylglycerol acyltransferase 1 (DGAT1), which catalyses the final step in triacylglycerol (TAG) assembly, is…
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2013
2013
A one-week phase 1 trial with the DGAT1 inhibitor AZD7687 : lipid handling, hormone secretion and adverse effects in the gut
H. Denison
,
C. Nilsson
,
+6 authors
J. Eriksson
2013
Corpus ID: 85883283
A one-week phase 1 trial with the DGAT1 inhibitor AZD7687 : lipid handling, hormone secretion and adverse effects in the gut
2012
2012
Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid…
Jonas G Barlind
,
U. Bauer
,
+19 authors
J. Vinblad
Journal of medicinal chemistry
2012
Corpus ID: 41703463
A new series of pyrazinecarboxamide DGAT1 inhibitors was designed to address the need for a candidate drug with good potency…
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