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AZD6140
Known as:
AZD 6140
, AZD-6140
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
Ticagrelor
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Ticagrelor: The First Reversibly Binding Oral P2Y12 Receptor Antagonist
S. Husted
,
J. V. van Giezen
Cardiovascular therapeutics
2009
Corpus ID: 8901207
Ticagrelor (AZD6140) is the first reversibly binding oral P2Y12 receptor antagonist that blocks ADP-induced platelet aggregation…
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Highly Cited
2009
Highly Cited
2009
Ticagrelor binds to human P2Y12 independently from ADP but antagonizes ADP‐induced receptor signaling and platelet aggregation
J. V. van Giezen
,
L. Nilsson
,
+4 authors
P. J. Greasley
Journal of thrombosis and haemostasis : JTH
2009
Corpus ID: 33086352
Summary. Background: P2Y12 plays an important role in regulating platelet aggregation and function. This receptor is the primary…
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Review
2008
Review
2008
P2 receptors, platelet function and pharmacological implications.
C. Gachet
Thrombosis and haemostasis
2008
Corpus ID: 6996844
ADP and ATP play a crucial role in platelet activation and their receptors are potential targets for antithrombotic drugs. The…
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Review
2008
Review
2008
Survival of heparins, oral anticoagulants, and aspirin after the year 2010.
J. Fareed
,
D. Hoppensteadt
,
+5 authors
R. Bick
Seminars in thrombosis and hemostasis
2008
Corpus ID: 30591099
The conventional management of thrombotic and cardiovascular disorders is based on the use of heparin, oral anticoagulants, and…
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Highly Cited
2007
Highly Cited
2007
Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes.
R. Storey
,
S. Husted
,
+8 authors
C. Cannon
Journal of the American College of Cardiology
2007
Corpus ID: 22880579
OBJECTIVES In a substudy of DISPERSE (Dose confIrmation Study assessing anti-Platelet Effects of AZD6140 vs. clopidogRel in non…
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Highly Cited
2007
Highly Cited
2007
Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute…
C. Cannon
,
S. Husted
,
+4 authors
R. Storey
Journal of the American College of Cardiology
2007
Corpus ID: 12978491
OBJECTIVES Our goal was to compare the safety and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate…
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Highly Cited
2007
Highly Cited
2007
From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.
Brian Springthorpe
,
Andrew Bailey
,
+26 authors
P. Willis
Bioorganic & medicinal chemistry letters
2007
Corpus ID: 19312973
Starting from adenosine triphosphate (ATP), the identification of a novel series of P2Y(12) receptor antagonists and exploitation…
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Review
2007
Review
2007
Clopidogrel resistance?
P. Gurbel
,
U. Tantry
Thrombosis research
2007
Corpus ID: 24370405
Clopidogrel is an effective inhibitor of platelet activation and aggregation due to its selective and irreversible blockade of…
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Highly Cited
2006
Highly Cited
2006
Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin.
S. Husted
,
H. Emanuelsson
,
S. Heptinstall
,
P. Sandset
,
M. Wickens
,
G. Peters
European heart journal
2006
Corpus ID: 43396500
AIMS This double-blind, parallel-group study was conducted to assess the pharmacodynamics, pharmacokinetics, and safety of…
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Review
2005
Review
2005
Preclinical and clinical studies with selective reversible direct P2Y12 antagonists.
J. V. van Giezen
,
R. Humphries
Seminars in thrombosis and hemostasis
2005
Corpus ID: 39760241
An important role for adenosine diphosphate (ADP)-induced platelet activation and aggregation was proposed more than 40 years ago…
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