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AZD6140

Known as: AZD 6140, AZD-6140 
 
National Institutes of Health

Papers overview

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Review
2009
Review
2009
Ticagrelor (AZD6140) is the first reversibly binding oral P2Y12 receptor antagonist that blocks ADP-induced platelet aggregation… Expand
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Highly Cited
2009
Highly Cited
2009
Summary.  Background: P2Y12 plays an important role in regulating platelet aggregation and function. This receptor is the primary… Expand
Review
2008
Review
2008
  • C. Gachet
  • Thrombosis and haemostasis
  • 2008
  • Corpus ID: 6996844
ADP and ATP play a crucial role in platelet activation and their receptors are potential targets for antithrombotic drugs. The… Expand
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Review
2008
Review
2008
The conventional management of thrombotic and cardiovascular disorders is based on the use of heparin, oral anticoagulants, and… Expand
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Highly Cited
2007
Highly Cited
2007
OBJECTIVES In a substudy of DISPERSE (Dose confIrmation Study assessing anti-Platelet Effects of AZD6140 vs. clopidogRel in non… Expand
Highly Cited
2007
Highly Cited
2007
OBJECTIVES Our goal was to compare the safety and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate… Expand
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Highly Cited
2007
Highly Cited
2007
Starting from adenosine triphosphate (ATP), the identification of a novel series of P2Y(12) receptor antagonists and exploitation… Expand
Review
2007
Review
2007
Clopidogrel is an effective inhibitor of platelet activation and aggregation due to its selective and irreversible blockade of… Expand
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Highly Cited
2006
Highly Cited
2006
AIMS This double-blind, parallel-group study was conducted to assess the pharmacodynamics, pharmacokinetics, and safety of… Expand
Review
2005
Review
2005
An important role for adenosine diphosphate (ADP)-induced platelet activation and aggregation was proposed more than 40 years ago… Expand