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AZD3965

Known as: MCT1 Inhibitor AZD3965, Monocarboxylate Transporter 1 Inhibitor AZD3965 
An orally available inhibitor of monocarboxylate transporter 1 (MCT1), with potential antineoplastic activity. Upon oral administration, MCT1… 
National Institutes of Health

Related topics

Related topics

3 relations
NCIt Antineoplastic Agent Terminology

Broader (2)

PyrimidinonesThiophenes

Papers overview

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2019
2019
Treatment of γ-Hydroxybutyric Acid and γ-Butyrolactone Overdose with Two Potent Monocarboxylate Transporter 1 Inhibitors, AZD3965 and AR-C155858
The illicit use of γ-hydroxybutyric acid (GHB), and its prodrug, γ-butyrolactone (GBL), results in severe adverse effects… 
2019
2019
The Association Between Mct1 T1470a And Ace I/d Polymorphisms And Athletic Status In Climbing Athletes
Previous studies have been reported that polymorphism is associated with injury in athlete and general populations. Some studies… 
2017
2017
MCT 1 inhibitor AZD 3965 increases mitochondrial metabolism , facilitating combination therapy and non-invasive magnetic resonance spectroscopy
Financial support: M Beloueche-Babari, S Wantuch, T Casals Galobart, M Koniordou, HG Parkes, V Arunan, Y-L Chung, TR Eykyn and MO… 
2017
2017
Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors
Cancers develop metabolic strategies to cope with their microenvironment often characterized by hypoxia, limited nutrient… 
2016
2016
Abstract 325: Evaluating the consequences of MCT1 inhibition in Burkitt lymphoma following treatment with AZD3965
Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA Many tumors display an altered metabolic… 
2015
2015
تأثیر تمرین تناوبی و نقش سن بر بیان ژنهای انتقالدهنده مونوکربوکسیلات (MCT1 و MCT4) و سطح لاکتات در عضلات اسکلتی موشهای صحرایی نر نژاد ویستار
2014
2014
Expressão do transportador de monocarboxilato MCT1 e sua proteína auxiliar CD 147 em hemácias de equinos de salto
2014
2014
Cancer Therapy : Preclinical Activity of the Monocarboxylate Transporter 1 Inhibitor AZD 3965 in Small Cell Lung Cancer
Purpose: The monocarboxylate transporter 1 (MCT1) inhibitor, AZD3965, is undergoing phase I evaluation in the United Kingdom… 
2013
2013
Abstract 5434: Inhibition of monocarboxylate transporter 1 as a therapeutic strategy in small cell lung cancer: target validation studies using the MCT1 inhibitor AZD3965.
Background. Small cell lung cancer (SCLC) accounts for ∼13% of lung cancers and frequently presents as disseminated or extensive… 
2012
2012
The Effects of Seven Weeks Endurance Training on Lactate Transportes Gene Expression in Skeletal Muscles of Wistar Rats
لوصو : 6 / 8 / 92 حلاصا : 11 / 9 / 92 شريذپ : 7 / 12 / 92… 
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