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AZD3839

National Institutes of Health

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2 relations

Broader (2)

IndolesPyrimidines

Papers overview

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2020
2020
A series of molecular modeling techniques to reveal selective mechanisms of inhibitors to β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) and β-site amyloid precursor protein cleaving…
Abstract Inhibition of β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) has been shown to be an effective treatment for… 
2016
2016
Reversible and Species-Specific Depigmentation Effects of AZD3293, a BACE Inhibitor for the Treatment of Alzheimer's Disease, Are Related to BACE2 Inhibition and Confined to Epidermis and Hair.
BACKGROUND AZD3293 (also known as LY3314814) is a novel, potent, non-selective BACE1/BACE2 inhibitor currently in Phase 3… 
2016
2016
Evaluation and Optimization of In Silico Designed B-Secretase Modulators for the Treatment of “ Alzheimer ’ s Disease ”
Alzheimer's disease affects cognitive function through formation of ßsecretase mediated extracellular cerebral protein plaques… 
2014
2014
Prediction and Modeling of Effects on the QTc Interval for Clinical Safety Margin Assessment, Based on Single-Ascending-Dose Study Data with AZD3839
Corrected QT interval (QTc) prolongation in humans is usually predictable based on results from preclinical findings. This study… 
2013
2013
Biotransformation of Two β-Secretase Inhibitors Including Ring Opening and Contraction of a Pyrimidine Ring
Recently, the discovery of the aminoisoindoles as potent and selective inhibitors of β-secretase was reported, including the… 
2012
2012
Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer
2012
2012
Preclinical characterization of AZD3839, a novel clinical candidate BACE1 inhibitor for the treatment of Alzheimer Disease
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