AZD3839

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2012-2016
012320122016

Papers overview

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2017
2017
The β-secretase (BACE1) initiates the generation of toxic amyloid-β peptide (Aβ) from amyloid-β precursor protein (APP), which… (More)
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2016
2016
BACKGROUND AZD3293 (also known as LY3314814) is a novel, potent, non-selective BACE1/BACE2 inhibitor currently in Phase 3… (More)
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2016
2016
Alzheimer's disease affects cognitive function through formation of ßsecretase mediated extracellular cerebral protein plaques… (More)
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2014
2014
Modulating deposition of Aβ-containing plaques in the brain may be beneficial in treating Alzheimer's disease. β-site amyloid… (More)
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2014
2014
Corrected QT interval (QTc) prolongation in humans is usually predictable based on results from preclinical findings. This study… (More)
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2013
2013
Time-dependent inhibition (TDI) of the cytochrome P450 (P450) family of enzymes is usually studied in human liver microsomes (HLM… (More)
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2013
2013
Recently, the discovery of the aminoisoindoles as potent and selective inhibitors of β-secretase was reported, including the… (More)
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2012
2012
β-Site amyloid precursor protein cleaving enzyme1 (BACE1) is one of the key enzymes involved in the processing of the amyloid… (More)
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2012
2012
The evaluation of a series of aminoisoindoles as β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and the… (More)
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2012
2012
Time-dependent inhibition (TDI) of the cytochrome P450 (P450) family of enzymes is usually studied in human liver microsomes (HLM… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?