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AZD3839

 
National Institutes of Health

Papers overview

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2020
2020
Inhibition of β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) has been shown to be an effective treatment for… Expand
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2017
2017
AbstractThe β-secretase (BACE1) initiates the generation of toxic amyloid-β peptide (Aβ) from amyloid-β precursor protein (APP… Expand
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2016
2016
BACKGROUND AZD3293 (also known as LY3314814) is a novel, potent, non-selective BACE1/BACE2 inhibitor currently in Phase 3… Expand
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2014
2014
Corrected QT interval (QTc) prolongation in humans is usually predictable based on results from preclinical findings. This study… Expand
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2014
2014
Modulating deposition of Aβ-containing plaques in the brain may be beneficial in treating Alzheimer's disease. β-site amyloid… Expand
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Review
2014
Review
2014
BACE1 (β-secretase, memapsin 2, Asp2) has emerged as a promising target for the treatment of Alzheimer's disease. BACE1 is an… Expand
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2013
2013
Time-dependent inhibition (TDI) of the cytochrome P450 (P450) family of enzymes is usually studied in human liver microsomes (HLM… Expand
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2013
2013
Recently, the discovery of the aminoisoindoles as potent and selective inhibitors of β-secretase was reported, including the… Expand
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2012
2012
β-Site amyloid precursor protein cleaving enzyme1 (BACE1) is one of the key enzymes involved in the processing of the amyloid… Expand
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2012
2012
The evaluation of a series of aminoisoindoles as β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and the… Expand
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