AZD 1152

Known as: AZD-1152, AZD1152, Aurora Kinase Inhibitor AZD1152 
 

Topic mentions per year

Topic mentions per year

2006-2018
024620062018

Papers overview

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2011
2011
The primary objective of this 2-part phase 1/2 study was to determine the maximum-tolerated dose (MTD) of the potent and… (More)
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2011
2011
Barasertib (AZD1152) is a highly potent and selective Aurora B kinase inhibitor. The safety, efficacy and pharmacokinetic (PK… (More)
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2010
2010
BACKGROUND & AIMS We previously identified that high Aurora B expression was associated with hepatocellular carcinoma (HCC… (More)
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2010
2010
In mammalian cells, the aurora kinases (aurora-A, -B, and -C) play essential roles in regulating cell division. The expression of… (More)
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2009
2009
Aurora kinases play a critical role in regulating mitosis and cell division, and their overexpression has been implicated in the… (More)
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2009
2009
The phenotypic change characteristic of Aurora B inhibition is the induction of polyploidy. Utilizing specific siRNA duplexes and… (More)
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2008
2008
Overexpression of the Aurora-B kinase correlates with oncogenic transformation and poor prognosis. We evaluated the effects of… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE In the current study, we examined the in vivo effects of AZD1152, a novel and specific inhibitor of Aurora kinase… (More)
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Highly Cited
2007
Highly Cited
2007
Aurora kinases play an important role in chromosome alignment, segregation, and cytokinesis during mitosis. We have recently… (More)
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Highly Cited
2007
Highly Cited
2007
The Aurora kinases have been the subject of considerable interest as targets for the development of new anticancer agents. While… (More)
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