barasertib

Known as: 1h-pyrazole-3-acetamide, 5-((7-(3-(ethyl(2-(phosphonooxy)ethyl)amino)propoxy)-4-quinazolinyl)amino)-n-(3-fluorophenyl)- 
An orally bioavailable, small-molecule, dihydrogen phosphate prodrug of the pyrazoloquinazoline Aurora kinase inhibitor AZD1152-hydroxyquinazoline… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2011-2017
0520112017

Papers overview

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2016
2016
Small-cell lung cancer (SCLC) cells have rapid proliferation, universal Rb inactivation, and high rates of MYC family… (More)
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2014
2014
The Aurora family is a well conserved and well characterized group of serine-threonine kinases involved in the normal progression… (More)
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2013
2013
INTRODUCTION Barasertib is the pro-drug of barasertib-hydroxy-quinazoline pyrazole anilide, a selective Aurora B kinase inhibitor… (More)
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2013
2013
BACKGROUND In this phase 2 study, the authors evaluated the efficacy, safety, and tolerability of the Aurora B kinase inhibitor… (More)
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2013
2013
We explored whether barasertib (AZD1152), a selective Aurora B kinase inhibitor, is a substrate for P-glycoprotein (Pgp, MDR1… (More)
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2012
2012
The purpose of this study was to determine the maximum-tolerated dose (MTD), pharmacokinetics and safety profile for two… (More)
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2012
2012
Barasertib (AZD1152) is a pro-drug that rapidly undergoes phosphatase-mediated cleavage in serum to release barasertib-hQPA, a… (More)
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2012
2012
Background:The Ras/RAF/MEK/ERK pathway is frequently deregulated in cancer and a number of inhibitors that target this pathway… (More)
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2011
2011
The primary objective of this 2-part phase 1/2 study was to determine the maximum-tolerated dose (MTD) of the potent and… (More)
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2011
2011
Barasertib (AZD1152) is a highly potent and selective Aurora B kinase inhibitor. The safety, efficacy and pharmacokinetic (PK… (More)
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