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ATB-346

National Institutes of Health

Papers overview

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2019
2019
THU0464 PHASE 2 CLINICAL TRIAL OF THE GI SAFETY OF A HYDROGEN SULFIDE-RELEASING ANTI-INFLAMMATORY DRUG (ATB-346)
Background: Hydrogen sulfide (H2S) is a naturally occurring gaseous mediator produced by intestinal bacteria and various… 
2018
2018
Influence of the slow- release H2S donor GYY4137 and the H2S- releasing naproxen derivative ATB-346 on postoperative ileus
2017
2017
Interactions between nitric oxide and hydrogen sulfide generating systems in gastric mucosa under condition of the combined action of stress and NDAIDs
Article history: Received on: 29/01/2017 Accepted on: 18/03/2017 Available online: 30/08/2017 The metabolic relationship between… 
2015
2015
THU0474 A Phase 1 Clinical Trial of ATB-346, A Gastrointestinal-Ssafe Nonsteroidal Anti-Inflammatory Drug
Background Hydrogen sulfide (H2S) is an endogenous signaling molecule that exerts powerful anti-inflammatory and cytoprotective… 
2014
2014
Effects of conventional and hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs in rats with stress-induced and epinephrine-induced gastric damage
Abstract Mechanisms of gastric defence under conditions of combined influence of acute stress and non-steroidal anti-inflammatory… 
2014
2014
[Parameters of NO synthase system of gastric mucosa in rats under stress conditions and inhibition of cyclooxygenase].
In experiments on rats with modeled water-restrained stress, the influence of nonsteroidal anti-inflammatory drugs of different… 
2014
2014
Effect of CCl4 and blocking H2S biosynthesis on oesophageal mucosa rats: model of nonerosive oesophagitis.
Nonerosive esophagitis (NEO) - a chronic inflammatory condition with diagnostic and therapy unclear approaches. The aim of study… 
2013
2013
P17 The H2S-releasing naproxen-derivative ATB-346 inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis
2012
2012
P9 Gastrointestinal-sparing effects of a hydrogen sulfide-releasing naproxen derivative in rats with compromised mucosal defence
2012
2012
P7 Chemo-preventative effects of a hydrogen sulfide-releasing naproxen derivative (ATB-346) in murine colorectal cancer
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