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ASF1A gene

Known as: CIA, DKFZP547E2110, CCG1-INTERACTING FACTOR A 
National Institutes of Health

Papers overview

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Highly Cited
2019
Highly Cited
2019
In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma.
Despite substantial progress in lung cancer immunotherapy, the overall response rate in KRAS-mutant lung adenocarcinoma (ADC… 
Highly Cited
2014
Highly Cited
2014
Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication
During DNA replication, nucleosomes are rapidly assembled on newly synthesized DNA to restore chromatin organization. Asf1, a key… 
Highly Cited
2014
Highly Cited
2014
Histone chaperone ASF1A is required for maintenance of pluripotency and cellular reprogramming
Factor in oocyte assists reprogramming Unfertilized eggs contain components that can dedifferentiate other cells that have gone… 
Highly Cited
2013
Highly Cited
2013
Placing the HIRA histone chaperone complex in the chromatin landscape.
Highly Cited
2011
Highly Cited
2011
Human CABIN1 Is a Functional Member of the Human HIRA/UBN1/ASF1a Histone H3.3 Chaperone Complex
ABSTRACT The mammalian HIRA/UBN1/ASF1a complex is a histone chaperone complex that is conserved from yeast (Saccharomyces… 
Highly Cited
2009
Highly Cited
2009
CBP/p300-mediated acetylation of histone H3 on lysine 56
Acetylation within the globular core domain of histone H3 on lysine 56 (H3K56) has recently been shown to have a critical role in… 
Highly Cited
2008
Highly Cited
2008
Human UBN1 Is an Ortholog of Yeast Hpc2p and Has an Essential Role in the HIRA/ASF1a Chromatin-Remodeling Pathway in Senescent Cells
ABSTRACT Cellular senescence is an irreversible proliferation arrest, tumor suppression process and likely contributor to tissue… 
Highly Cited
2007
Highly Cited
2007
Structure and function of the histone chaperone CIA/ASF1 complexed with histones H3 and H4
CIA (CCG1-interacting factor A)/ASF1, which is the most conserved histone chaperone among the eukaryotes, was genetically… 
Highly Cited
2006
Highly Cited
2006
Structure of a human ASF1a–HIRA complex and insights into specificity of histone chaperone complex assembly
Human HIRA, ASF1a, ASF1b and CAF-1 are evolutionally conserved histone chaperones that form multiple functionally distinct… 
Highly Cited
2005
Highly Cited
2005
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA.
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