Characterization of two different Asf1 histone chaperones with distinct cellular localizations and functions in Trypanosoma brucei

@inproceedings{Pascoalino2014CharacterizationOT,
  title={Characterization of two different Asf1 histone chaperones with distinct cellular localizations and functions in Trypanosoma brucei},
  author={Bruno Pascoalino and G{\"u}lcin Dindar and Jo{\~a}o Pedro Vieira-da-Rocha and Carlos Renato Machado and Christian J. Janzen and Sergio Schenkman},
  booktitle={Nucleic acids research},
  year={2014}
}
The anti-silencing function protein 1 (Asf1) is a chaperone that forms a complex with histones H3 and H4 facilitating dimer deposition and removal from chromatin. Most eukaryotes possess two different Asf1 chaperones but their specific functions are still unknown. Trypanosomes, a group of early-diverged eukaryotes, also have two, but more divergent Asf1 paralogs than Asf1 of higher eukaryotes. To unravel possible different functions, we characterized the two Asf1 proteins in Trypanosoma brucei… CONTINUE READING
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