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AS602868

National Institutes of Health

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Broader (1)

Pyrimidines

Papers overview

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2011
2011
Inhibition of IGF-1 Signalling Enhances the Apoptotic Effect of AS602868, an IKK2 Inhibitor, in Multiple Myeloma Cell Lines
Multiple myeloma (MM) is a B cell neoplasm characterized by bone marrow infiltration with malignant plasma cells. IGF-1… 
Highly Cited
2008
Highly Cited
2008
Tumor Necrosis Factor-α Regulates Inflammatory and Mesenchymal Responses via Mitogen-Activated Protein Kinase Kinase, p38, and Nuclear Factor κB in Human Endometriotic Epithelial Cells
Tumor necrosis factor (TNF)-α is central to the endometriotic disease process. TNF-α receptor signaling regulates epithelial cell… 
2008
2008
Preclinical targeting of NF-κB and FLT3 pathways in AML cells
To date, only 20–30% of acute myeloid leukemia (AML) patients escape relapse to achieve long-term survival,1 demonstrating the… 
2007
2007
Targeting the NF-kappaB pathway through pharmacological inhibition of IKK2 prevents human cytomegalovirus replication and virus-induced inflammatory response in infected endothelial cells.
2007
2007
AS602868, a dual inhibitor of IKK2 and FLT3 to target AML cells
Acute myeloid leukemia (AML) cells carry molecular defects that promote their leukemic proliferation, resistance to apoptosis and… 
Highly Cited
2006
Highly Cited
2006
NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription.
Abnormal expression of TGF-beta1 is believed to play an important role in the pathogenesis of a number of chronic inflammatory… 
2006
2006
IkappaB kinase 2 inhibition corrects defective nitrergic erectile mechanisms in diabetic mouse corpus cavernosum.
Highly Cited
2005
Highly Cited
2005
Targeting NF-κB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells
Acute myeloid leukemia (AML) cells are characterized by a constitutive and abnormal activation of the nuclear factor-κB (NF-κB… 
2004
2004
IKK2 inhibitor alleviates kidney and wasting diseases in a murine model of human AIDS.
Highly Cited
2003
Highly Cited
2003
AS602868, a pharmacological inhibitor of IKK2, reveals the apoptotic potential of TNF-α in Jurkat leukemic cells
NF-κB transcription factors promote survival in numerous cell types via induction of antiapoptotic genes. Pharmacological… 
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