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AS1413

National Institutes of Health

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amonafide L-malate

Papers overview

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2010
2010
Abstract 3665: The novel DNA intercalator amonafide (AS1413), disrupts the cell cycle by mechanisms distinct from those of Topo II inhibitors daunorubicin and etoposide
Amonafide-L-malate (amonafide, AS1413) is a novel DNA intercalator that induces apoptosis through mechanisms involving… 
2010
2010
A phase IIa pharmacokinetic and efficacy study of amonafide (AS1413) in combination with cytarabine in patients with acute myeloid leukemia.
TPS278 Background: Amonafide is a novel DNA intercalator that is not affected by multidrug resistance mechanisms, a common cause… 
2009
2009
Abstract #1700: Amonafide (AS1413) intercalates into DNA and is a unique inhibitor of DNA Topoisomerase II
Amonafide (AS1413, amonafide L-malate) has shown activity in phase I and II clinical trials in patients with secondary AML (sAML…