AS1411

Known as: AS 1411, AS-1411, Anti-Nucleolin Aptamer AS1411 
A 26-base guanine-rich oligodeoxynucleotide aptamer with potential apoptotic induction activity. Upon administration, anti-nucleolin aptamer AS1411… (More)

Topic mentions per year

Topic mentions per year

1996-2018
0102019962018

Papers overview

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2015
2015
Aptamers are single-stranded RNA or DNA ligands that can specifically bind to various molecular targets with high affinity. Owing… (More)
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2015
2015
AS1411 is a G-rich quadruplex-forming oligodeoxynucleotide that binds specifically to nucleolin, a protein found on the surface… (More)
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2014
2014
BRAF gene mutation is found in more than 60% of malignant melanomas, which are difficult to treat. In this study, a new tumor… (More)
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2013
2013
Over recent years, cell surface nucleolin as an anticancer target has attracted many researchers' attentions. To improve the… (More)
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2012
2012
Liposomes and polymers are widely used drug carriers for controlled release since they offer many advantages like increased… (More)
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Highly Cited
2011
Highly Cited
2011
Targeted delivery of therapeutic nanoparticles in a disease-specific manner represents a potentially powerful technology… (More)
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Highly Cited
2010
Highly Cited
2010
AS1411 is a first-in-class anticancer agent, currently in phase II clinical trials. It is a quadruplex-forming… (More)
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2009
2009
AS1411 is a DNA aptamer that is in phase II clinical trials for relapsed or refractory acute myeloid leukemia and for renal cell… (More)
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Highly Cited
2008
Highly Cited
2008
We sought to determine whether nucleolin, a bcl-2 mRNA-binding protein, has a role in the regulation of bcl-2 mRNA stability in… (More)
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Highly Cited
2007
Highly Cited
2007
AS1411 is a quadruplex-forming oligonucleotide aptamer that targets nucleolin. It is currently in clinical trials as a treatment… (More)
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