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AS1411

Known as: AS 1411, AS-1411, Anti-Nucleolin Aptamer AS1411 
A 26-base guanine-rich oligodeoxynucleotide aptamer with potential apoptotic induction activity. Upon administration, anti-nucleolin aptamer AS1411… 
National Institutes of Health

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Broader (1)

AGRO 100
NCIt Antineoplastic Agent Terminology

Papers overview

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2015
2015
Label-free electrochemical aptasensor constructed by layer-by-layer technology for sensitive and selective detection of cancer cells.
2015
2015
Tumor targeting with a 99mTc-labeled AS1411 aptamer in prostate tumor cells
Abstract AS1411, a 26-base guanine-rich oligonucleotide aptamer, has high affinity to nucleolin, mainly on tumor cell surfaces… 
2015
2015
Synthesis of fluorescent dye-doped silica nanoparticles for target-cell-specific delivery and intracellular microRNA imaging.
MicroRNA (miRNA) is found to be up-regulated in many kinds of cancer and therefore is classified as an oncomiR. Herein, we design… 
2015
2015
Visual detection of mercury(II) based on recognition of the G-quadruplex conformational transition by a cyanine dye supramolecule.
A supramolecular probe for visual detection of mercury (Hg) has been designed by using a cyanine dye and AS1411 G-quadruplexes… 
2015
2015
Study of the Function of G-Rich Aptamers Selected for Lung Adenocarcinoma.
Guanine (G)-rich oligonucleotides have attracted considerable interest as therapeutic agents. Two G-rich aptamers were selected… 
2011
2011
Simple PEG Modification of DNA Aptamer Based on Copper Ion Coordination for Tumor Targeting
A simple modification of a DNA aptamer with poly(ethylene glycol) (PEG) based on metal coordination was developed. N,N-bis… 
2009
2009
PRMT 5 , a Novel TRAIL Receptor-Binding Protein , Inhibits TRAIL-Induced Apoptosis via Nuclear Factor-κ B Activation
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily and has selective… 
2009
2009
G-rich oligonucleotides for cancer treatment.
Oligonucleotides with guanosine-rich (G-rich) sequences often have unusual physical and biological properties, including… 
2007
2007
Activity and Mechanism of Action of AS1411 in Acute Myeloid Leukemia Cells.
AS1411 is a 26 base unmodified DNA aptamer which is currently in a Phase II clinical trial for the treatment of acute myeloid… 
2006
2006
A role for protein arginine methyltransferase 5 (PRMT5) in the mechanism of novel anticancer agent, AS1411.
Proc Amer Assoc Cancer Res, Volume 47, 2006 5507 AS1411 (formerly AGRO100) is a guanosine-rich phosphodiester… 
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