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AS 605240

Known as: AS-605240, AS605240 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
A blockade of PI3Kγ signaling effectively mitigates angiotensin II-induced renal injury and fibrosis in a mouse model
Chronic kidney disease (CKD) poses a formidable challenge for public healthcare worldwide as vast majority of patients with CKD… 
2017
2017
PI3Kγ Deficient NOD-Mice Are Protected from Diabetes by Restoring the Balance of Regulatory to Effector-T-Cells
With a steady increase in its incidence and lack of curative treatment, type 1 diabetes (T1D) has emerged as a major health… 
2017
2017
Downregulation of PI3K‐&ggr; in a mouse model of sepsis‐induced myocardial dysfunction
2016
2016
Prolactin potentiates the activity of acid-sensing ion channels in female rat primary sensory neurons
2010
2010
Targeting PI3K in neuroblastoma
PurposeThis work employs pharmacological targeting of phosphoinositide 3-kinases (PI3K) in selected neuroblastoma (NB) tumors… 
2010
2010
Effects of PI3Kgamma inhibition using AS-605240 in acute myocardial infarction.
To the Editor: We read with interest the article by Siragusa et al1 showing a protective effect of phosphoinositide-3 kinase… 
2009
2009
Phosphoinositide 3-kinase gamma inhibitor ameliorates concanavalin A-induced hepatic injury in mice.
2009
2009
[Intervention effect of PI3Kgamma inhibitor AS605240 on autoimmune myocarditis in mice].
OBJECTIVE To investigate the therapeutic effect of PI3Kgamma inhibitor AS605240 on autoimmune myocarditis in mice. METHODS BALB… 
2006
2006
Phosphoinositide 3-kinase-γ as a target in rheumatoid arthritis and systemic lupus
Rheumatoid arthritis and systemic lupus erythematosus are autoimmune diseases, which may involve phosphoinositide 3-kinase gamma… 
2005
2005
Modulating autoimmunity: pick your PI3 kinase
Small molecules that specifically inhibit PI3Kγ block disease in mouse models of arthritis and lupus (pages 936–943). 
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