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The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse
TLDR
The presence of the inflammasome in the mouse heart in an experimental mouse model of AMI as evidenced by increased caspase-1 activity and cytoplasmic aggregates of the three components of theInflammasomes may represent a unique therapeutic strategy to limit cell death and prevent heart failure after AMI. Expand
Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function.
TLDR
AMI is followed by enhanced spontaneous mobilization of BMSC, in particular, in patients on statin therapy and following a primary percutaneous intervention, which might contribute to determine a more favourable post-AMI remodelling. Expand
A systematic review and meta-analysis on the hazards of discontinuing or not adhering to aspirin among 50,279 patients at risk for coronary artery disease.
TLDR
Non-compliance or withdrawal of aspirin treatment has ominous prognostic implication in subjects with or at moderate-to-high risk for CAD and aspirin discontinuation in such patients should be advocated only when bleeding risk clearly overwhelms that of atherothrombotic events. Expand
Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials.
TLDR
Meta-regression suggested the existence of a dose-response association between injected cell volume and LVEF change and support further multicenter randomized trials targeted to address the impact of intracoronary cell therapy on overall and event-free long-term survival. Expand
Metabolic Gene Remodeling and Mitochondrial Dysfunction in Failing Right Ventricular Hypertrophy Secondary to Pulmonary Arterial Hypertension
TLDR
Right ventricular dysfunction, but not functional RV hypertrophy in rats, demonstrates a gene expression profile compatible with a multilevel impairment of fatty acid metabolism and significant mitochondrial dysfunction, partially independent of chronic pressure-overload. Expand
Targeting interleukin-1 in heart disease.
TLDR
Interleukin-1 (IL-1) is an apical proinflammatory mediator in acute and chronic inflammation and a powerful inducer of the innate immune response and this step is key in the pathogenesis of many autoinflammatory diseases. Expand
Adjusted indirect comparison meta-analysis of prasugrel versus ticagrelor for patients with acute coronary syndromes.
TLDR
Prasugrel and ticagrelor are superior to clopidogrel for ACS, but prasugrel appears more protective from stent thrombosis, while causing more bleedings. Expand
Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study).
TLDR
In the present pilot study of patients with ST-segment elevation AMI, IL-1 blockade with anakinra was safe and favorably affected by LV remodeling and might represent a novel therapeutic strategy to prevent heart failure after AMI. Expand
Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats.
TLDR
Adrenergic receptor blockade reverses RV remodeling and improves RV function in experimental pulmonary hypertension in rats, and is not recommended in humans with PAH before their safety and efficacy are assessed in well-designed clinical trials. Expand
Increased myocardial apoptosis in patients with unfavorable left ventricular remodeling and early symptomatic post-infarction heart failure.
TLDR
The data show that in patients dying >or=10 days after AMI, myocardial apoptosis is strongly associated with and may be a major determinant of unfavorable LV remodeling and early symptomatic post-infarction HF. Expand
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