FAQ

ARGININOSUCCINATE LYASE

Known as: Argininosuccinase, Argininosuccinate Lyase [Chemical/Ingredient], N-(L-Argininosuccinate) arginine-lyase 
An enzyme of the urea cycle which splits argininosuccinate to fumarate plus arginine. Its absence leads to the metabolic disease ARGININOSUCCINIC… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1960-2018
051019602018

Related topics

Related topics

12 relations
ASL geneArgininosuccinic AciduriaIn BloodProcess of secretion
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Broader (1)

Amidine-Lyases

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
ARGININOSUCCINATE LYASE
physiological aspects
chemical synthesis
standards characteristics
Argininosuccinic Aciduria
Process of secretion

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis.
Necrotizing enterocolitis (NEC), the most common neonatal gastrointestinal emergency, results in significant mortality and… (More)
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2009
2009
Functional complementation in yeast allows molecular characterization of missense argininosuccinate lyase mutations.
Deficiency of argininosuccinate lyase (ASL) causes argininosuccinic aciduria, an urea cycle defect that may present with a severe… (More)
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2001
2001
Three-dimensional structure of the argininosuccinate lyase frequently complementing allele Q286R.
Argininosuccinate lyase (ASL) catalyzes the reversible breakdown of argininosuccinate to arginine and fumarate, a reaction… (More)
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2001
2001
Mechanisms for intragenic complementation at the human argininosuccinate lyase locus.
Argininosuccinate lyase (ASL) is a homotetrameric enzyme that catalyzes the reversible cleavage of argininosuccinate to arginine… (More)
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2000
2000
Two novel mutations (E86A, R113W) in argininosuccinate lyase deficiency and evidence for highly variable splicing of the human argininosuccinate lyase gene
DeÐciency of argininosuccinate lyase (ASLD; McKusick 207900) is a rare autosomal recessively inherited metabolic disease a†ecting… (More)
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1997
1997
Human argininosuccinate lyase: a structural basis for intragenic complementation.
Intragenic complementation has been observed at the argininosuccinate lyase (ASL) locus. Intragenic complementation is a… (More)
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1991
1991
Characterization of the human argininosuccinate lyase gene and analysis of exon skipping.
A cosmid clone containing the entire human argininosuccinate lyase gene was isolated and characterized. The gene is approximately… (More)
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Highly Cited
1989
Highly Cited
1989
The argininosuccinate lyase gene of Chlamydomonas reinhardtii: an important tool for nuclear transformation and for correlating the genetic and molecular maps of the ARG7 locus.
The argininosuccinate lyase (ASL) gene of Chlamydomonas reinhardtii has been cloned using four oligonucleotide probes… (More)
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1988
1988
Amino acid sequence of rat argininosuccinate lyase deduced from cDNA.
Argininosuccinate lyase [EC 4.3.2.1] is an enzyme of the urea cycle in the liver of ureotelic animals. The enzymes of the urea… (More)
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1981
1981
Argininosuccinate lyase: purification and characterization from human liver.
Argininosuccinate lyase has been purified to near homogeneity and partially characterized from extracts of human liver. The… (More)
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