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ARGININOSUCCINATE LYASE

Known as: Argininosuccinase, Argininosuccinate Lyase [Chemical/Ingredient], N-(L-Argininosuccinate) arginine-lyase 
An enzyme of the urea cycle which splits argininosuccinate to fumarate plus arginine. Its absence leads to the metabolic disease ARGININOSUCCINIC… Expand
National Institutes of Health

Related topics

Related topics

13 relations
ASL geneArgininosuccinate lyase:CCnt:Pt:CVS:QnArgininosuccinate lyase:CCnt:Pt:Liver^fetus:QnArgininosuccinate lyase:CCnt:Pt:RBC:Qn
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Broader (1)

Amidine-Lyases

Papers overview

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Highly Cited
2013
Highly Cited
2013
Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma
Arginine deprivation, either by nutritional starvation or exposure to ADI-PEG20, induces adaptive transcriptional upregulation of… Expand
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Highly Cited
2012
Highly Cited
2012
Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1.
Nitric oxide (NO) defends against intracellular pathogens, but its synthesis must be regulated due to cell and tissue toxicity… Expand
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Highly Cited
2011
Highly Cited
2011
Requirement of argininosuccinate lyase for systemic nitric oxide production
Nitric oxide (NO) is crucial in diverse physiological and pathological processes. We show that a hypomorphic mouse model of… Expand
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Highly Cited
2010
Highly Cited
2010
Regulation of cellular metabolism by protein lysine acetylation.
Protein lysine acetylation has emerged as a key posttranslational modification in cellular regulation, in particular through the… Expand
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Highly Cited
2004
Highly Cited
2004
Neurodevelopmental outcome of long-term therapy of urea cycle disorders in Japan
In Japan, urea cycle disorders (UCDs) are one of the most frequent inborn errors of metabolism, estimated to have a prevalence of… Expand
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Highly Cited
2001
Highly Cited
2001
Tandem mass spectrometric analysis for amino, organic, and fatty acid disorders in newborn dried blood spots: a two-year summary from the New England Newborn Screening Program.
BACKGROUND Tandem mass spectrometry (MS/MS) is rapidly being adopted by newborn screening programs to screen dried blood spots… Expand
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1996
1996
Coinduction of nitric oxide synthase, argininosuccinate synthetase, and argininosuccinate lyase in lipopolysaccharide-treated rats. RNA blot, immunoblot, and immunohistochemical analyses.
Nitric oxide (NO) is synthesized from arginine by nitric oxide synthase (NOS), and citrulline which is generated can be recycled… Expand
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Highly Cited
1989
Highly Cited
1989
The argininosuccinate lyase gene of Chlamydomonas reinhardtii: an important tool for nuclear transformation and for correlating the genetic and molecular maps of the ARG7 locus.
The argininosuccinate lyase (ASL) gene of Chlamydomonas reinhardtii has been cloned using four oligonucleotide probes… Expand
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Highly Cited
1988
Highly Cited
1988
Gene sharing by delta-crystallin and argininosuccinate lyase.
The lens structural protein delta-crystallin and the metabolic enzyme argininosuccinate lyase (ASL; L-argininosuccinate arginine… Expand
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Review
1986
Review
1986
Biosynthesis and metabolism of arginine in bacteria.
INTRODUCTION ...................................................... 315 BIOSYNTHESIS OF ARGININE… Expand
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