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ARG2 gene

Known as: ARG2, ARGINASE 2 
National Institutes of Health

Related topics

Related topics

1 relation
arginase II, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Mitochondrial Arginase-2 is a cell autonomous regulator of CD8+ T cell function and anti-tumor efficacy.
As sufficient extracellular arginine is crucial for T cell function, depletion of extracellular arginine by elevated Arginase 1… 
Highly Cited
2018
Highly Cited
2018
Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.
2018
2018
Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma.
Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate here… 
2017
2017
Arginine metabolic endotypes related to asthma severity
Aims Arginine metabolism via inducible nitric oxide synthase (iNOS) and arginase 2 (ARG2) is higher in asthmatics than in healthy… 
Highly Cited
2016
Highly Cited
2016
Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection
We reported that arginase 2 (ARG2) deletion results in increased gastritis and decreased bacterial burden during Helicobacter… 
Highly Cited
2015
Highly Cited
2015
Arginase 2 deficiency results in spontaneous steatohepatitis: a novel link between innate immune activation and hepatic de novo lipogenesis.
Highly Cited
2014
Highly Cited
2014
ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis
Impaired autophagy function and enhanced ARG2 (arginase 2)-MTOR (mechanistic target of rapamycin) crosstalk are implicated in… 
2013
2013
IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension.
Although previous literature suggests that interleukin (IL)-13, a T-helper type 2 cell effector cytokine, might be involved in… 
Highly Cited
2010
Highly Cited
2010
Androgen-Regulated Expression of Arginase 1, Arginase 2 and Interleukin-8 in Human Prostate Cancer
Background Prostate cancer (PCa) is the most frequently diagnosed cancer in North American men. Androgen-deprivation therapy (ADT… 
2008
2008
Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression
In human prostate cancer, Arginase 2 (ARG2) and nitric oxide synthase (NOS) are concomitantly expressed by tumor cells, and… 
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