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AQX-1125

National Institutes of Health

Papers overview

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Review
2018
Review
2018
Response to Current Pharmacologic Approaches in Painful Bladder Research: An Update
Copyright © 2018 Korean Continence Society This is an Open Access article distributed under the terms of the Creative Commons… 
Review
2016
Review
2016
Investigational drugs for bladder pain syndrome (BPS) / interstitial cystitis (IC)
ABSTRACT Introduction: Bladder pain syndrome (BPS)/interstitial cystitis (IC) is associated with sensory lower urinary tract… 
2016
2016
MP24-17 PERVASIVE BIOFILM COVERAGE: AN ANALYSIS OF BIOFILM FORMATION IN INDWELLING URINARY CATHETERS
2016
2016
MP72-17 EFFECT OF AQX-1125 ON URINARY BLADDER INFLAMMATION AND PAIN INDUCED BY CYCLOPHOSPHAMIDE IN RATS, BY TARGETING THE SHIP1 PATHWAY
2016
2016
MP24-16 PLASMA AND URINARY PHARMACOKINETICS OF A NOVEL, ORAL SHIP1 ACTIVATOR AQX-1125 IN FEMALE PATIENTS WITH INTERSTITIAL CYSTITIS
2016
2016
Pain: SHIP-1 activation for IC/BPS?
Moderate-to-severe abacterial interstitial cystitis/bladder pain syndrome (IC/BPS) remains largely untreatable, resulting in… 
2016
2016
427 Plasma and urinary pharmacokinetics of the novel, oral SHIP1 activator, AQX-1125 in interstitial cystitis/bladder pain syndrome (IC/BPS): Results of the phase2 LEADERSHIP trial
2013
2013
The effect of the novel SHIP1 activator AQX-1125 on allergen-induced responses in mild to moderate asthma
Rationale: SH2-containing inositol phosphatase-1 (SHIP1) is an endogenous inhibitor of the phosphoinositide-3-kinase pathway that… 
2012
2012
AQX-1125, A SHIP1 Activator, Inhibits Chemotaxis In Vitro And Exerts Pleiotropic Anti-Inflammatory Effects In A Rodent Model Of Endotoxin-Induced Pulmonary Inflammation
Rationale: Pharmacological modulation of the phosphoinositide 3-kinase (PI3K)/Akt pathway is an established approach to… 
2011
2011
AQX-1125, a Modulator of the SHIP1/PI3K Pathway, Suppresses Chemotaxis and Inflammation
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