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APS Gene

Known as: Adaptor Protein with Pleckstrin Homology and SRC Homology 2 Domains Gene, SH2B2, APS 
This gene is involved in signal transduction and plays a role in insulin-mediated glucose uptake.
National Institutes of Health

Related topics

Related topics

5 relations
APS protein, humanB-Cell ActivationSH2B2 geneSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Chronic disease in childhood and adolescence: continuity of care in the Health Care Network.
OBJECTIVE To evaluate the continuity of care for children and adolescents with chronic diseases in the health care network… 
2017
2017
Age effect on prevalence of ultra-high risk for psychosis symptoms: replication in a clinical sample of an early detection of psychosis service
Higher frequencies of perceptual and lesser clinical significance of non-perceptual attenuated psychotic symptoms (APS) have been… 
Review
2013
Review
2013
The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.
Unlike prototypical receptor tyrosine kinases (RTKs), which are single-chain polypeptides, the insulin receptor (InsR) is a… 
2007
2007
APS-mediated ubiquitination of the insulin receptor enhances its internalization, but does not induce its degradation.
APS, a tyrosine kinase adaptor protein with pleckstrin homology and Src homology 2 domains, is rapidly and strongly tyrosine… 
2005
2005
The interaction between the adaptor protein APS and Enigma is involved in actin organisation.
2004
2004
Increased Numbers of B-1 Cells and Enhanced Responses against TI-2 Antigen in Mice Lacking APS, an Adaptor Molecule Containing PH and SH2 Domains
ABSTRACT APS (adaptor molecule containing PH and SH2 domains) is an intracellular adaptor protein that forms an adaptor family… 
Highly Cited
2003
Highly Cited
2003
The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit.
The adapter protein APS has previously been shown to be involved in recruiting the ubiquitin E3 ligase c-Cbl to the insulin… 
Highly Cited
2001
Highly Cited
2001
Four PSM/SH2-B Alternative Splice Variants and Their Differential Roles in Mitogenesis*
An SH2 domain originally termed SH2-B had been identified as a direct cellular binding target of a number of mostly mitogenic… 
Highly Cited
2000
Highly Cited
2000
Identification of a New Class of 5′-Adenylylsulfate (APS) Reductases from Sulfate-Assimilating Bacteria
ABSTRACT A gene was cloned from Burkholderia cepacia DBO1 that is homologous with Escherichia coli cysH encoding 3… 
Highly Cited
1997
Highly Cited
1997
Immunoprecipitation of steroidogenic enzyme autoantigens with autoimmune polyglandular syndrome type I (APS I) sera; further evidence for independent humoral immunity to P450c17 and P450c21
Three steroidogenic P450 cytochromes, steroid 17α‐hydroxylase (P450c17), steroid 21‐hydroxylase (P450c21) and side‐chain cleavage… 
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