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APH1A gene

Known as: APH-1A, ANTERIOR PHARYNX DEFECTIVE 1, C. ELEGANS, HOMOLOG OF, A, APH1A 
National Institutes of Health

Papers overview

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2017
2017
Retraction Note: Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a
Gingerol is a major dietary compound that occurs in several plants belonging to the Zingiberaceae family. In the current study… 
2012
2012
Different types of γ-secretes complexes and their effect on substrate processing
The γ-secretase complex is a transmembrane aspartyl protease that generates the Alzheimer disease (AD) related amyloid β-peptide… 
2010
2010
Localization and trafficking of endogenous anterior pharynx-defective 1, a component of Alzheimer's disease related γ-secretase
2008
2008
Chemical Cross-linking Provides a Model of the γ-Secretase Complex Subunit Architecture and Evidence for Close Proximity of the C-terminal Fragment of Presenilin with APH-1*
γ-Secretase is an intramembrane cleaving aspartyl protease complex intimately implicated in Alzheimer disease pathogenesis. The… 
2008
2008
Interaction between the APOE epsilon4 allele and the APH-1b c + 651T > G SNP in Alzheimer's disease.
The gamma-secretase complex is a multimeric aspartyl protease which plays a pivotal role in the production of amyloid beta… 
2007
2007
Study on the Putative Contribution of Caspases and the Proteasome to the Degradation of Aph-1a and Pen-2
The presenilin-dependent γ-secretase complex is mainly composed of four distinct proteins, namely presenilin 1 or presenilin 2… 
2005
2005
Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes.
2005
2005
Identification and characterization of a novel human APH-1b splice variant lacking exon 4.
2004
2004
Co-expression of Nicastrin and Presenilin Rescues a Loss of Function Mutant of APH-1*
γ-Secretase is an intramembrane-cleaving aspartyl protease complex that mediates the final cleavage of β-amyloid precursor… 
2004
2004
O4-02-06 Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain
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