APH1A gene

Known as: APH-1A, ANTERIOR PHARYNX DEFECTIVE 1, C. ELEGANS, HOMOLOG OF, A, APH1A 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2003-2017
024620032017

Papers overview

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2010
2010
Gamma-secretase is a multiprotein, intramembrane-cleaving protease with a growing list of protein substrates, including the Notch… (More)
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2009
2009
Gamma-secretase is a unique intramembrane-cleaving protease complex, which cleaves the Alzheimer's disease-associated beta… (More)
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2006
2006
The proteolytic cleavage of Alzheimer beta-amyloid precursor protein (APP) and signaling receptor Notch is mediated by the PS… (More)
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2005
2005
APH-1 (anterior pharynx defective) along with nicastrin and PEN-2 (presenilin enhancer) are essential components of the… (More)
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Highly Cited
2004
Highly Cited
2004
Gamma-secretase is a high molecular weight protein complex composed of four subunits, namely, presenilin (PS; 1 or 2), nicastrin… (More)
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2004
2004
The -secretase complex catalyzes the final intramembraneous cleavage of the -amyloid precursor protein, liberating the neurotoxic… (More)
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2004
2004
The gamma-secretase complex catalyzes the final intramembraneous cleavage of the beta-amyloid precursor protein, liberating the… (More)
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2004
2004
Gamma-secretase is a member of a new class of proteases with an intramembrane catalytic site and cleaves numerous type I membrane… (More)
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2004
2004
In vitro reconstitution of functions of membrane proteins is often hampered by aggregation, misfolding, or lack of post… (More)
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2003
2003
APH-1 and PEN-2 genes modulate the function of nicastrin and the presenilins in Caenorhabditis elegans. Preliminary studies in… (More)
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