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Isolation of Antiosteoporotic Compounds from Seeds of Sophora japonica
TLDR
Histopathologically, sophoricoside ameliorated the ovarectomy induced osteoporosis in a dose dependent manner and the drug showed thicker bony trabeculae, more osteoid, and more osteoblastic rimming compared to OVX group. Expand
New xanthones and cytotoxic constituents from Garcinia mangostana fruit hulls against human hepatocellular, breast, and colorectal cancer cell lines.
TLDR
The mechanism of antiproliferative/cytotoxic effects of the tested compounds was investigated and it was found that only 5 induced significant cell cycle arrest at G0/G1-phase which is indicative of its antiprolifierative properties. Expand
Antidiabetic and Antioxidant Activities of Major Flavonoids of Cynanchum acutum L. (Asclepiadaceae) Growing in Egypt
TLDR
Seven flavonoids were isolated from the butanol fraction of the methanolic extract of the aerial parts of Cynanchum acutum L. (Asclepiadaceae) and were found to exhibit significant antioxidant and antidiabetic activities (by measuring blood glucose and insulin levels). Expand
Repurposing of Some Natural Product Isolates as SARS-COV-2 Main Protease Inhibitors via In Vitro Cell Free and Cell-Based Antiviral Assessments and Molecular Modeling Approaches
TLDR
A systematic computer-aided virtual screening approach was carried out using commercially available natural products found on the Zinc Database in addition to an in-house compound library to identify potential natural product inhibitors of SARS-CoV-2 main protease (MPRO). Expand
Saudi plants as a source of potential β-lactamase inhibitors.
TLDR
Results revealed that selected plant extracts showed no antibacterial activity against tested strains; meanwhile, only Echinops viscosus, Pulicaria arabica, Tephrosia nubica, Chrozophora oblongifolia, and Clutia myricoides showed pronounced ESβL inhibitory activities. Expand
Phenolics from Garcinia mangostana alleviate exaggerated vasoconstriction in metabolic syndrome through direct vasodilatation and nitric oxide generation
TLDR
The phenolic compounds 2, 4, and 5 ameliorated the exaggerated vasoconstriction in MetS aortae through vasodilatation-NO generation mechanism. Expand
Integracides H-J: New tetracyclic triterpenoids from the endophytic fungus Fusarium sp.
TLDR
Three new tetracyclic triterpenoids namely, integracides H (1), I (4), and J (5) have been isolated from the endophytic fungus Fusarium sp. Expand
Mangostanaxanthones III and IV: advanced glycation end-product inhibitors from the pericarp of Garcinia mangostana
TLDR
All of the isolated xanthones significantly inhibited both sugar (ribose) and dicarbonyl compound (methylglyoxal)-induced protein glycation in a dose-dependent manner, explained by the ability of the isolate to inhibit protein oxidation. Expand
Phenolics from Garcinia mangostana Inhibit Advanced Glycation Endproducts Formation: Effect on Amadori Products, Cross-Linked Structures and Protein Thiols
TLDR
Investigation of the inhibitory effect of bioactive metabolites isolated from fruit hulls of Garcinia mangostana on AGE formation found phenolic compounds 1–4 inhibited AGEs formation at the levels of Amadori product and protein aggregation formation through saving protein thiol. Expand
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