FAQ

ANGPTL3 gene

Known as: ANGIOPOIETIN 5, ANGIOPOIETIN-LIKE 3, ANGPTL3 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2018
051019992018

Papers overview

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2017
2017
ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.
BACKGROUND Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid… (More)
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2017
2017
Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.
BACKGROUND Loss-of-function variants in the angiopoietin-like 3 gene (ANGPTL3) have been associated with decreased plasma levels… (More)
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2015
2015
Hepatic ANGPTL3 regulates adipose tissue energy homeostasis.
Angiopoietin-like protein 3 (ANGPTL3) is a circulating inhibitor of lipoprotein and endothelial lipase whose physiological… (More)
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Highly Cited
2012
Highly Cited
2012
Atypical angiopoietin-like protein that regulates ANGPTL3.
Angiopoietin-like proteins (ANGPTLs) play major roles in the trafficking and metabolism of lipids. Inactivation of ANGPTL3, a… (More)
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2012
2012
Prevalence of ANGPTL3 and APOB gene mutations in subjects with combined hypolipidemia.
OBJECTIVE Mutations of the ANGPTL3 gene have been associated with a novel form of primary hypobetalipoproteinemia, the combined… (More)
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2012
2012
Characterization of three kindreds with familial combined hypolipidemia caused by loss-of-function mutations of ANGPTL3.
BACKGROUND Angiopoietin-like protein 3 (ANGPTL3) affects lipid metabolism by inhibiting the activity of lipoprotein and… (More)
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2009
2009
Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL).
Angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) are secreted proteins that regulate triglyceride (TG) metabolism… (More)
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2003
2003
Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo.
Angiopoietin-like 3 (ANGPTL3) is a secreted protein that is mainly expressed in the liver and regulates lipid metabolism by… (More)
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Highly Cited
2002
Highly Cited
2002
ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase.
KK/San is a mutant mouse strain established in our laboratory from KK obese mice. KK/San mice show low plasma lipid levels… (More)
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Highly Cited
2002
Highly Cited
2002
ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo.
The angiopoietin family of secreted factors is functionally defined by the C-terminal fibrinogen (FBN)-like domain, which… (More)
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