Peroxisome Proliferator-Activated Receptor Alpha Target Genes
- M. Rakhshandehroo, B. Knoch, Michael Müller, S. Kersten
- Biology, ChemistryPPAR Research
- 26 September 2010
An overview of the involvement of PPARα in lipid metabolism and other pathways through a detailed analysis of the different known or putative PPAR α target genes is presented.
Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans.
Roles of PPARs in health and disease
The latest developments in the PPAR field are presented, with particular emphasis on the physiological function ofPPARs during various nutritional states, and the possible role of PPARs in several chronic diseases.
Characterization of the Fasting-induced Adipose Factor FIAF, a Novel Peroxisome Proliferator-activated Receptor Target Gene*
- S. Kersten, S. Mandard, W. Wahli
- Biology, Computer ScienceJournal of Biological Chemistry
- 15 September 2000
The data suggest that FIAF represents a novel endocrine signal involved in the regulation of metabolism, especially under fasting conditions, and is strongly up-regulated by fasting in white adipose tissue and liver.
Physiological regulation of lipoprotein lipase.
- S. Kersten
- BiologyBiochimica et Biophysica Acta
- 1 July 2014
Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting.
- S. Kersten, J. Seydoux, J. Peters, F. Gonzalez, B. Desvergne, W. Wahli
- BiologyJournal of Clinical Investigation
It is shown that to accommodate the increased requirement for hepatic fatty acid oxidation, PPAR alpha mRNA is induced during fasting in wild-type mice, indicating that PPARalpha plays a pivotal role in the management of energy stores during fasting.
Mechanisms of nutritional and hormonal regulation of lipogenesis
- S. Kersten
- Biology, MedicineEMBO Reports
- 1 April 2001
This work has established that sterol regulatory element binding protein‐1 is a critical intermediate in the pro‐ or anti‐lipogenic action of several hormones and nutrients in lipogenesis.
Peroxisome proliferator-activated receptor α target genes
- S. Mandard, M. Müller, S. Kersten
- Biology, ChemistryCellular and Molecular Life Sciences (CMLS)
- 1 February 2004
The involvement of PPAR α in peroxisomal and mitochondrial fatty acid oxidation, microsomal fatty acid hydroxylation, lipoprotein, bile and amino acid metabolism, glucose homeostasis, biotransformation, inflammation control, hepato-carcinogenesis and other pathways is reviewed through a detailed analysis of the different known or putative PPARα target genes.
Nutrigenomics: goals and strategies
Applied wisely, nutrigenomics will allow effective dietary-intervention strategies to recover normal homeostasis and to prevent diet-related diseases.
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
It is shown that to accommodate the increased requirement for hepatic fatty acid oxidation, PPAR α mRNA is induced during fasting in wildtype mice, indicating that PPARα plays a pivotal role in the management of energy stores during fasting.