AMD3100

Known as: AMD 3100, AMD-3100, SDZ SID 791 
A bicyclam with hematopoietic stem cell-mobilizing properties. AMD3100 blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular… (More)

Topic mentions per year

Topic mentions per year

1996-2018
05019962018

Papers overview

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Highly Cited
2009
Highly Cited
2009
The CXCR4-SDF-1 axis plays a central role in the trafficking and retention of normal and malignant stem cells in the bone marrow… (More)
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Highly Cited
2009
Highly Cited
2009
The bicyclam AMD3100 is known as a small synthetic inhibitor of the CXCL12-binding chemokine receptor CXCR4. Here, we show that… (More)
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Highly Cited
2009
Highly Cited
2009
The interaction of multiple myeloma (MM) cells with their microenvironment in the bone marrow (BM) provides a protective… (More)
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Highly Cited
2008
Highly Cited
2008
Allografts from HLA-matched sibling donors were mobilized and collected without granulocyte colony-stimulating factor (G-CSF… (More)
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Highly Cited
2005
Highly Cited
2005
Improving approaches for hematopoietic stem cell (HSC) and hematopoietic progenitor cell (HPC) mobilization is clinically… (More)
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Highly Cited
2005
Highly Cited
2005
Hematopoietic progenitor cells (HPCs) traffic to and are retained in the marrow through the trophic effects of the chemokine… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE Interactions between the chemokine receptor CXCR4 and its ligand stromal derived factor-1 regulate hematopoietic stem… (More)
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Highly Cited
2003
Highly Cited
2003
Stromal cell-derived factor 1 (SDF1/CXCL12) and its cognate receptor, CXCR4, play key regulatory roles in CD34+ cell trafficking… (More)
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Highly Cited
2002
Highly Cited
2002
This study was undertaken to demonstrate the unique specificity of the chemokine receptor CXCR4 antagonist AMD3100. Calcium flux… (More)
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Highly Cited
1998
Highly Cited
1998
The bicyclam AMD3100 (formula weight 830) blocks HIV-1 entry and membrane fusion via the CXCR4 co-receptor, but not via CCR5… (More)
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