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AM336

Known as: AM 336, AM-336, CVID, calcium channel blocker 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

CNSB004

Broader (1)

omega-Conotoxins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Microbial transformations of halolactones with p-menthane system.
2013
2013
Novel ω-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration
BackgroundAntagonists of N-type voltage-gated calcium channels (VGCC), Cav2.2, can manage severe chronic pain with intrathecal… 
2013
2013
Lactones 41.† Synthesis and Microbial Hydroxylation of Unsaturated Terpenoid Lactones with p-Menthane Ring Systems
Racemic [(±)-4-isopropyl-1-methyl-7-oxa-cis-bicyclo[4.3.0]non-4-en-8-one] and optically active δ,ε-unsaturated lactones [(-)-(1R… 
2011
2011
Intravenous injection of leconotide, an omega conotoxin: synergistic antihyperalgesic effects with morphine in a rat model of bone cancer pain.
OBJECTIVE Leconotide (CVID, AM336, CNSB004) is an omega conopeptide similar to ziconotide, which blocks voltage sensitive calcium… 
2010
2010
Enantioselectivity of hydroxylation of racemic piperitone by fungi.
The biotransformation of racemic piperitone ((±)-1) was investigated using four strains of fungi selected in the screening… 
Review
2008
Review
2008
Future Directions for Intrathecal Pain Management: A Review and Update From the Interdisciplinary Polyanalgesic Consensus Conference 2007
Background.  Expert panels of physicians and nonphysicians, all expert in intrathecal (IT) therapies, convened in the years 2000… 
2005
2005
Block of Voltage-Gated Calcium Channels by Peptide Toxins
Peptide toxins that selectively block voltage sensitive calcium channels have contributed enormously to our understanding of the… 
2004
2004
Development of small molecules that mimic the binding of ω-conotoxins at the N-type voltage-gated calcium channel
Cone snails (Conidae) are marine predators with some extraordinary features. Their venom contains a hundred or more peptides that… 
2003
2003
Development of a method for the direct analysis of peptide AM336 in monkey cerebrospinal fluid using liquid chromatography/electrospray ionization mass spectrometry with a mixed-function column.
A liquid chromatography/mass spectrometry (LC/MS) analytical procedure, using a single column for sample clean-up, enrichment and… 
Highly Cited
2002
Highly Cited
2002
The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices
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