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Venomous marine cone snails produce a unique and remarkably diverse range of venom peptides (conotoxins and conopeptides) that… Expand BackgroundAntagonists of N-type voltage-gated calcium channels (VGCC), Cav2.2, can manage severe chronic pain with intrathecal… Expand Racemic [(±)-4-isopropyl-1-methyl-7-oxa-cis-bicyclo[4.3.0]non-4-en-8-one] and optically active δ,ε-unsaturated lactones [(-)-(1R… Expand OBJECTIVE
Leconotide (CVID, AM336, CNSB004) is an omega conopeptide similar to ziconotide, which blocks voltage sensitive calcium… Expand Background. Expert panels of physicians and nonphysicians, all expert in intrathecal (IT) therapies, convened in the years 2000… Expand Peptide toxins that selectively block voltage sensitive calcium channels have contributed enormously to our understanding of the… Expand Cone snails (Conidae) are marine predators with some extraordinary features. Their venom contains a hundred or more peptides that… Expand A liquid chromatography/mass spectrometry (LC/MS) analytical procedure, using a single column for sample clean-up, enrichment and… Expand Agents which decrease conductance of N-type voltage-gated Ca(2+) channels have been shown to attenuate measures of neuropathic… Expand &NA; N‐type calcium channels modulate the release of key pro‐nociceptive neurotransmitters such as glutamate and substance P (SP… Expand