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ALPL gene

Known as: Alkaline Phosphatase, Liver/Bone/Kidney Gene, TNAP, ALKALINE PHOSPHATASE, TISSUE-NONSPECIFIC 
This gene may play a role in matrix mineralization.
National Institutes of Health

Related topics

Related topics

5 relations
ALPL protein, humanAlkaline PhosphataseDephosphorylationHydrolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Reappearance of hypomineralized bone after discontinuation of asfotase alfa treatment for severe childhood hypophosphatasia
2017
2017
Specific knock‐down of tissue non‐specific alkaline phosphatase mRNA levels inhibits intracellular lipid accumulation in 3T3‐L1 and HepG2 cells
The use of non‐specific inhibitors of tissue non‐specific alkaline phosphatase (TNSALP) in pre‐adipocytes blocks intracellular… 
Review
2015
Review
2015
TNAP and Pain Control.
Chronic pain is one of the most debilitating and expensive diseases, yet current therapies are often insufficient in bringing… 
Review
2015
Review
2015
Genetically Modified Mice for Studying TNAP Function.
Genetically modified mice are powerful tools for understanding the functions of genes and proteins and often serve as models of… 
Review
2014
Review
2014
[Mineralization of cartilage in growth plate].
Endochondral ossification is an essential process for skeletal development, in which chondrocyte undergoes apoptosis and induces… 
2013
2013
Association of mineralization-related genes TNAP and ANKH polymorphisms with ankylosing spondylitis in the Chinese Han population.
The aim of this study was to investigate two mineralization-related genes TNAP and ANKH polymorphisms associated with ankylosing… 
2012
2012
Hypophosphatasia: enzyme replacement therapy (ENB-0040) decreases TNSALP substrate accumulation and improves functional outcome in affected adolescents and adults
Review
2007
Review
2007
[Pyrophosphate and mineralization (TNSALP, PC-1, ANK)].
Pyrophosphate inhibits mineralization, and tissue non-specific alkaline phosphatase (TNSALP) increases phosphate concentration by… 
2001
2001
Identification of pulmonary surfactant that bears intestinal-type and tissue-nonspecific-type alkaline phosphatase in endotoxin-induced rat bronchoalveolar fluid
Abstract. The characteristics of lipopolysaccharide (LPS)-induced alkaline phosphatase (AP) isozymes on the various pulmonary… 
1999
1999
Expression of mRNA Encoding Tissue-Nonspecific Alkaline Phosphatase in Human Dental Tissues
Abstract. Tissue-nonspecific-type alkaline phosphatase (TNSALP) is found in the bone, liver, kidney, and other tissues, and its… 
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