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ALKBH2 gene

Known as: ABH2, AlkB, E. COLI, HOMOLOG OF, 2, alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Oncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions.
Cancer-associated mutations often lead to perturbed cellular energy metabolism and accumulation of potentially harmful… Expand
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Highly Cited
2012
Highly Cited
2012
DNA repair is indispensable for survival after acute inflammation.
More than 15% of cancer deaths worldwide are associated with underlying infections or inflammatory conditions, therefore… Expand
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2012
2012
Duplex Interrogation by a Direct DNA Repair Protein in Search of Base Damage
ALKBH2 is a direct DNA repair dioxygenase guarding the mammalian genome against N1-methyladenine, N3-methylcytosine and 1,N6… Expand
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Highly Cited
2010
Highly Cited
2010
The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA.
The ABH8 protein (also called ALKBH8) is a member of the AlkB (alkylated DNA repair protein) family of nonheme iron… Expand
Highly Cited
2009
Highly Cited
2009
Nickel Ions Inhibit Histone Demethylase JMJD1A and DNA Repair Enzyme ABH2 by Replacing the Ferrous Iron in the Catalytic Centers*
Iron- and 2-oxoglutarate-dependent dioxygenases are a diverse family of non-heme iron enzymes that catalyze various important… Expand
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Highly Cited
2008
Highly Cited
2008
Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA
Escherichia coli AlkB and its human homologues ABH2 and ABH3 repair DNA/RNA base lesions by using a direct oxidative dealkylation… Expand
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Highly Cited
2008
Highly Cited
2008
AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA.
Endogenous formation of the mutagenic DNA adduct 1,N(6)-ethenoadenine (epsilon A) originates from lipid peroxidation. Elevated… Expand
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Highly Cited
2005
Highly Cited
2005
Repair of Methylation Damage in DNA and RNA by Mammalian AlkB Homologues*
Human and Escherichia coli derivatives of AlkB enzymes remove methyl groups from 1-methyladenine and 3-methylcytosine in nucleic… Expand
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Highly Cited
2003
Highly Cited
2003
Minimal Methylated Substrate and Extended Substrate Range of Escherichia coli AlkB Protein, a 1-Methyladenine-DNA Dioxygenase*
The Escherichia coli AlkB protein, and two human homologs ABH2 and ABH3, directly demethylate 1-methyladenine and 3… Expand
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Highly Cited
2002
Highly Cited
2002
Reversal of DNA alkylation damage by two human dioxygenases
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the DNA lesions 1… Expand
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