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ALKBH2 gene

Known as: ABH2, AlkB, E. COLI, HOMOLOG OF, 2, alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase 
 
National Institutes of Health

Papers overview

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2015
2015
Emulsion PCR significantly improves nonequilibrium capillary electrophoresis of equilibrium mixtures-based aptamer selection: allowing for efficient and rapid selection of aptamer to unmodified ABH2…
Nonequilibrium capillary electrophoresis of equilibrium mixtures (NECEEM), a homogeneous approach to select DNA aptamers, is… Expand
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2013
2013
ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression.
The ALKBH family of proteins are highly expressed in various types of human cancer where they are involved in tumor growth and… Expand
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2012
2012
DNA repair is indispensable for survival after acute inflammation.
More than 15% of cancer deaths worldwide are associated with underlying infections or inflammatory conditions, therefore… Expand
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2010
2010
Mechanistic insight into the recognition of single-stranded and double-stranded DNA substrates by ABH2 and ABH3.
The human ABH2 and ABH3 proteins are functionally complementary in the oxidative demethylation of N(1)-methyl adenine (1-meA) and… Expand
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Highly Cited
2010
Highly Cited
2010
The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA.
The ABH8 protein (also called ALKBH8) is a member of the AlkB (alkylated DNA repair protein) family of nonheme iron… Expand
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Highly Cited
2008
Highly Cited
2008
Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA
Escherichia coli AlkB and its human homologues ABH2 and ABH3 repair DNA/RNA base lesions by using a direct oxidative dealkylation… Expand
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Highly Cited
2008
Highly Cited
2008
AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA.
Endogenous formation of the mutagenic DNA adduct 1,N(6)-ethenoadenine (epsilon A) originates from lipid peroxidation. Elevated… Expand
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Highly Cited
2005
Highly Cited
2005
Repair of methylation damage in DNA and RNA by mammalian AlkB homologues.
Human and Escherichia coli derivatives of AlkB enzymes remove methyl groups from 1-methyladenine and 3-methylcytosine in nucleic… Expand
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2003
2003
Minimal methylated substrate and extended substrate range of Escherichia coli AlkB protein, a 1-methyladenine-DNA dioxygenase.
The Escherichia coli AlkB protein, and two human homologs ABH2 and ABH3, directly demethylate 1-methyladenine and 3… Expand
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Highly Cited
2002
Highly Cited
2002
Reversal of DNA alkylation damage by two human dioxygenases.
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the DNA lesions 1… Expand
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