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AL 4114

Known as: AL-4114, ALO 4114, ALO-4114 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

FluorenesHydantoinsSpiro Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Oxidation of Aldose Reductase Inhibitors AL 0-4114 and AL 0-3152 Catalyzed by Liver Microsomes
Ariens, "Nonchiral, Homochiral and Composite Chiral Drugs' Trends in Pharmacologica Sciences 14:68–G35172 5 (Feb. 1993). DuPriest… 
2000
2000
Effects of aldose reductase inhibitors on antioxidant defense in rat and rabbit liver.
Aldose reductase has been implicated in the etiology of diabetic complications, atherosclerosis, and ischemia-reperfusion injury… 
1998
1998
Mitochondrial aldehyde reductase: identification and characterization in rat liver and kidney cortex.
1995
1995
Minimal effects of two aldose reductase inhibitors, AL-1576 and AL-4114, after subacute topical-ocular dosing on xenobiotic biotransformation in rabbits.
Aldose reductase is believed to be involved in teh etiology of diabetic complications, including cataractogenesis, nephropathy… 
1992
1992
The efficacy of aldose reductase inhibitors on polyol accumulation in human lens and retinal pigment epithelium in tissue culture.
The formation of excess sugar alcohol mediated by aldose reductase (AR) and its intracellular accumulation in lens with resultant… 
1992
1992
Oxidation of aldose reductase inhibitors ALO-4114 and ALO-3152 catalyzed by liver microsomes.
Rat and Cynomolgus monkey liver microsomes catalyze the oxidation of 2.7-difluoro-4.5-dimethoxyspiro (9H-fluorene-9,4… 
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