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AKAP11 gene

Known as: A-kinase anchoring protein 11, AKAP 220, A-kinase anchoring protein, 220kDa 
National Institutes of Health

Papers overview

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2018
2018
Multiple Functional Variants at 13q14 Risk Locus for Osteoporosis Regulate RANKL Expression Through Long‐Range Super‐Enhancer
RANKL is a key regulator involved in bone metabolism, and a drug target for osteoporosis. The clinical diagnosis and assessment… 
2016
2016
AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption
Significance Systemic control of water homeostasis is a vital physiological process. Vasopressin-regulated reabsorption of water… 
2014
2014
PKA Compartmentalization via AKAP220 and AKAP12 Contributes to Endothelial Barrier Regulation
cAMP-mediated PKA signaling is the main known pathway involved in maintenance of the endothelial barrier. Tight regulation of PKA… 
2012
2012
Genome-wide association analysis of Sasang constitution in the Korean population.
OBJECTIVES Sasang constitutional medicine is a traditional Korean medicine in which an individual is classified into one of four… 
2011
2011
Isoform-specific targeting of PKA to multivesicular bodies
PKA RIα subunit is localized to MVBs by the A-kinase–anchoring protein AKAP11 when disassociated from the PKA catalytic subunit. 
2008
2008
AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts.
During dehydration, protein kinase A phosphorylates aquaporin 2 (AQP2) at serine 256 and this is essential for apical membrane… 
Highly Cited
2002
Highly Cited
2002
A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.
Glycogen synthase kinase-3 (GSK-3) is regulated by various extracellular ligands and phosphorylates many substrates, thereby… 
Highly Cited
2001
Highly Cited
2001
Multiple Interactions within the AKAP220 Signaling Complex Contribute to Protein Phosphatase 1 Regulation*
The phosphorylation status of cellular proteins is controlled by the opposing actions of protein kinases and phosphatases… 
Highly Cited
2000
Highly Cited
2000
Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis.
Using a combination of protein kinase A type II overlay screening, rapid amplification of cDNA ends, and database searches, a… 
Highly Cited
1999
Highly Cited
1999
Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220
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