AG-221

Known as: IDH2 Inhibitor AG-221 
An orally available inhibitor of isocitrate dehydrogenase type 2 (IDH2), with potential antineoplastic activity. Upon administration, AG-221… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2014-2018
02420142018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Somatic gain-of-function mutations in isocitrate dehydrogenases (IDH) 1 and 2 are found in multiple hematologic and solid tumors… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
2017
2017
AG-221 or enasidenib is a first-in-class selective inhibitor of mutated isocitrate dehydrogenase 2 (IDH2) with early demonstrated… (More)
Is this relevant?
2017
2017
We thank the patients who participated in these trials and their families, as well as the investigators and staff at all MMY-3012… (More)
  • figure 1
  • figure 2
Is this relevant?
2017
2017
Genomic studies in acute myeloid leukemias (AML) have identified mutations that drive altered DNA methylation, including TET2 and… (More)
Is this relevant?
2016
2016
VOLUME 34 NUMBER 8 AUGUST 2016 NATURE BIOTECHNOLOGY which helps tumor cells cope with oxidative stress. CB-839 is the first… (More)
  • table 1
Is this relevant?
Review
2016
Review
2016
Isocitrate dehydrogenase (IDH) is a metabolic enzyme that converts isocitrate to α-ketoglutarate (α-KG). Genetic gain-of-function… (More)
Is this relevant?
Review
2016
Review
2016
Small-molecule inhibitors of the phosphoinositide 3-kinase (PI3K), Akt, and mTOR pathway currently in the clinic produce a… (More)
  • table 1
  • figure 1
Is this relevant?
2015
2015
Blastic plasmacytoid dendritic cell neoplasm is an exceedingly rare hematologic malignancy derived from the precursors of… (More)
Is this relevant?
2015
2015
Genetic abnormalities including specific point mutations have recently been confirmed by applying comprehensive genome sequencing… (More)
Is this relevant?
Review
2015
Review
2015
Isocitrate dehydrogenase (IDH) catalyzes the conversion of isocitrate to alpha ketoglutarate. IDH occurs in three isoforms, IDH1… (More)
Is this relevant?