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AG 14361

Known as: AG-14361, AG14361 
National Institutes of Health

Papers overview

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2016
2016
Resveratrol Attenuates Aβ25–35 Caused Neurotoxicity by Inducing Autophagy Through the TyrRS-PARP1-SIRT1 Signaling Pathway
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the accumulation of β-amyloid peptide (Aβ) and loss of… 
2014
2014
Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast…
Breast cancer is a devastating disease that results in approximately 40,000 deaths each year in the USA. Current drug screening… 
2011
2011
Response of allograft of BRCA1+/+ and BRCA1-/- mammary tumor cells to AG14361
2010
2010
The use of poly(ADP-ribose) polymerase (PARP1) inhibitors (AG14361, AZD2281, ABT888) in combination with capecitabine, 5-fluorouracil, or paclitaxel in the treatment of hereditary and sporadic breast…
e13120 Background: Poly(ADP-ribose) polymerase (PARP-1) inhibitors have been reported to enhance the cytotoxicity of alkylating… 
2010
2010
Abstract 5400: Targeting the PI3K pathway improves the effect of PARP-1 inhibition in BRCA1-null breast cancer cells
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC The development of targeted therapies has greatly… 
2010
2010
Abstract 663: The comparative efficacy of the PARP inhibitors AG14361, ABT888 and AZD2281 in the treatment of triple negative and BRCA1 breast cancer
Introduction: Most preclinical studies have used “in vitro” animal cell lines, “in vivo” allografts and/or gene knockdowns to… 
2010
2010
Abstract P6-15-04: Targeting the PI3K Pathway Enhances the Effect of PARP-1 Inhibition in BRCA1 Deficient Breast Cancer Cells
Background: Available targeted therapies have improved the prognosis for many women diagnosed with breast cancer. However, more… 
2008
2008
Exploiting the Achilles heel of cancer: the therapeutic potential of poly(ADP-ribose) polymerase inhibitors in BRCA2-defective cancer.
Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates DNA single-strand break-base excision repair to maintain genomic stability… 
2007
2007
The Enhancement of Paclitaxel Cytotoxicity in Hereditary and Sporadic Breast Cancer by the Poly(ADP) Ribose Polymerase Inhibitor AG14361
Among the most successful chemotherapy regimens in the treatment of breast cancer are those that include the anti‐mitotic agent… 
2003
2003
Kinase and Poly ( ADP-Ribose ) Polymerase-1 ProteinCombined Use of Novel Inhibitors of DNA-dependent Radiosensitization and DNA Repair Inhibition by the Updated Version
The DNA repair enzymes, DNA-dependent protein kinase (DNA-PK) and poly(ADP-ribose) polymerase-1 (PARP-1), are key determinants of… 
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