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AG 1295

Known as: AG-1295, AG1295, Tyrphostin AG 1295 
A member of the Tyrphostin family of tyrosine kinase inhibitors that inhibits signal transduction through platelet-derived growth factor receptor and… 
National Institutes of Health

Related topics

Related topics

1 relation
Receptor Tyrosine Kinase Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Enhanced levels of endogenous endothelin-1 contribute to the over expression of Giα protein in vascular smooth muscle cells from SHR: Role of growth factor receptor activation.
2009
2009
BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3.
Constitutively activating internal tandem duplications (ITD) of FLT3 (FMS-like tyrosine kinase 3) are the most common mutations… 
2006
2006
Involvement of insulin-like growth factor type 1 receptor and protein kinase Cdelta in bis(maltolato)oxovanadium(IV)-induced phosphorylation of protein kinase B in HepG2 cells.
Vanadium(IV) oxo-bis(maltolato) (BMOV), an organovanadium compound, is a potent insulinomimetic agent and improves glucose… 
Highly Cited
2005
Highly Cited
2005
Enforced expression of an Flt3 internal tandem duplication in human CD34+ cells confers properties of self-renewal and enhanced erythropoiesis.
To investigate the role of constitutively active internal tandem duplication (ITD) mutants of the Fms-like tyrosine kinase 3… 
2004
2004
The involvement of platelet-derived growth factor receptors and insulin-like growth factor-I receptors signaling during mineralized nodule formation by human periodontal ligament cells.
BACKGROUND AND OBJECTIVE Periodontal ligament cells are regarded to have the capacity to differentiate into cementoblasts or… 
2002
2002
IL-13-induced Clara cell secretory protein expression in airway epithelium: role of EGFR signaling pathway.
Previous work showed that the Th2 cytokine interleukin (IL)-13 induces goblet cell metaplasia via an indirect mechanism involving… 
Highly Cited
2001
Highly Cited
2001
A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations.
Internal tandem duplication (ITD) mutations of the receptor tyrosine kinase FLT3 have been found in 20% to 30% of patients with… 
2000
2000
Receptor tyrosine kinase inhibition suppresses growth of pediatric renal tumor cells in vitro.
PURPOSE Children who undergo standard therapy for renal tumors are at an increased risk for treatment sequelae such as congestive… 
Highly Cited
2000
Highly Cited
2000
Local delivery of platelet-derived growth factor receptor-specific tyrphostin inhibits neointimal formation in rats.
Signal transduction through the platelet-derived growth factor (PDGF)/PDGF receptor (PDGFR) system is involved in the process of… 
1999
1999
Tyrosine kinase inhibitors as antiproliferative agents against an estrogen‐dependent breast cancer cell line in vitro
Receptor tyrosine kinase (RTK) activation is critical for growth factor‐mediated cell proliferation. Blockade of RTK activation… 
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